autonomic failure

autonomic failure

A condition characterised by sympathetic and often parasympathetic failure. AF can be divided into primary, secondary and drug-induced forms, with considerable overlap.
 
Aetiology
AF may be evoked by or associated with ageing, alcohol consumption, carcinomatous autonomic neuropathy, CNS disease, dopamine beta-hydroxylase deficiency, familial dysautonomia (Riley-Day syndrome), idiopathic orthostatic hypotension, Parkinson’s disease, and Shy-Drager syndrome.

Clinical findings
Syncope, orthostatic hypotension.

autonomic failure

Neurology A condition characterized by sympathetic and often parasympathetic failure; Clinical Syncope, orthostatic hypotension; AF can be divided into 1º, 2º, and drug-induced forms with considerable overlap Etiology AF may be evoked by or associated with aging, alcohol imbibition, carcinomatous autonomic neuropathy, CNS disease, dopamine β-hydroxylase deficiency, familial dysautonomia or Riley-Day syndrome, idiopathic orthostatic hypotension, Parkinson's disease, Shy-Drager syndrome. See Baroreflex failure.
References in periodicals archive ?
nOH is a rare disease that occurs in people with an existing disease of the brain, spinal cord, or peripheral nerves, including Parkinson's disease, multiple system atrophy (MSA), and pure autonomic failure (PAF).
NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associated with Parkinson's disease, multiple-system atrophy, and pure autonomic failure.
2) The most definitive publication on autonomic failure was published in a comprehensive book in 1983.
There was no evidence that participants had heart problems or autonomic failure (a nervous system disorder) causing fainting, and no twin pair reported a family history of sudden cardiac death.
Approximately 74% of patients exhibit autonomic failure, 87% experience Parkinsonism, 54% experience cerebellar ataxia, and 49% exhibit pyramidal signs such as paralysis, muscle weakness, loss of muscle control, and tremor.
Northera (droxidopa), the lead investigational agent in Chelsea Therapeutics' broad pipeline, is currently in Phase III clinical trials for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with primary autonomic failure -- a group of diseases that includes Parkinson's disease, multiple system atrophy (MSA) and pure autonomic failure (PAF).
of the 11 patients, 7 had pure autonomic failure (PAF), 3 Parkinson disease (2 with persistent, consistent orthostatic hypotension), and 1 multiple system atrophy (MSA).
Also included are chapters on the evaluation of autonomic failure, catecholamine disorders, central and peripheral disorders (catecholamine disorders and cardiovascular disorders were my favorite chapters).
SAN ANTONIO -- Acarbose is a novel effective therapy for postprandial hypotension in patients with autonomic failure, Dr.
has announced that the FDA has granted Orphan Drug designation to its drug candidate Droxidopa for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with Primary Autonomic Failure, a group of diseases that includes Parkinson's Disease, Pure Autonomic Failure (PAF) and Multiple Systems Atrophy (MSA).
Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy.
Hypoglycemia-associated autonomic failure in diabetes.

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