nOH is a rare disease that occurs in people with an existing disease of the brain, spinal cord, or peripheral nerves, including Parkinson's disease, multiple system atrophy (MSA), and pure autonomic failure
NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associated with Parkinson's disease, multiple-system atrophy, and pure autonomic failure
2) The most definitive publication on autonomic failure
was published in a comprehensive book in 1983.
There was no evidence that participants had heart problems or autonomic failure
(a nervous system disorder) causing fainting, and no twin pair reported a family history of sudden cardiac death.
Approximately 74% of patients exhibit autonomic failure
, 87% experience Parkinsonism, 54% experience cerebellar ataxia, and 49% exhibit pyramidal signs such as paralysis, muscle weakness, loss of muscle control, and tremor.
Northera (droxidopa), the lead investigational agent in Chelsea Therapeutics' broad pipeline, is currently in Phase III clinical trials for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with primary autonomic failure
-- a group of diseases that includes Parkinson's disease, multiple system atrophy (MSA) and pure autonomic failure
of the 11 patients, 7 had pure autonomic failure
(PAF), 3 Parkinson disease (2 with persistent, consistent orthostatic hypotension), and 1 multiple system atrophy (MSA).
Also included are chapters on the evaluation of autonomic failure
, catecholamine disorders, central and peripheral disorders (catecholamine disorders and cardiovascular disorders were my favorite chapters).
SAN ANTONIO -- Acarbose is a novel effective therapy for postprandial hypotension in patients with autonomic failure
has announced that the FDA has granted Orphan Drug designation to its drug candidate Droxidopa for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with Primary Autonomic Failure
, a group of diseases that includes Parkinson's Disease, Pure Autonomic Failure
(PAF) and Multiple Systems Atrophy (MSA).
Consensus statement on the definition of orthostatic hypotension, pure autonomic failure
, and multiple system atrophy.
Hypoglycemia-associated autonomic failure