Adult patients with standard-risk ALL who undergo allogeneic transplant in the first complete remission have a significant survival advantage over conventional therapy; however, the transplant-related mortality for high-risk older patients was unacceptably high and abrogated the reduction in relapse risk," he said, adding that there is no evidence that a single autologous transplant can replace standard consolidation/maintenance therapy in any risk group.
Significant differences among the groups were found, however, with regard to overall survival, which stood at 52% for the chemotherapy patients, 46% for the allogeneic group, and 43% for the autologous transplant patients.
Up to 10 percent of bone marrow donors fail to mobilize sufficient numbers of stem cells, which impedes autologous transplants and significantly delays transplant recovery time," said Hartmut Geiger, Ph.
However, the chemotherapy agents associated with autologous transplants can have long-lasting cardiopulmonary, immunosuppressive, renal, and other side effects that affect quality of life (Buchsel & Whedon, 1995).
In addition, several new cancer services have been developed, using advanced treatment and diagnostic technologies, such as; the Hamad Positron Emission Tomograpy/ Computed Tomography Centre; NCCCR's CyberKnife; adaptive brachytherapy to treat cervical cancers; Magnetic Resonance-Guided focused Ultra Sound to treat bone metastases and the Hematopoietic Stem Cell Transplant Programme, currently being used to provide autologous transplants to patients with hematological cancers.
The Council will also hear presentations and discussions on the following topics: Arizona reimbursement concerns for Medicaid beneficiaries; Myelodysplastic Syndromes (MDS) coverage; Medicare reimbursement for costs for allogeneic or autologous transplants, legislative reauthorization and appropriations bills; and Program performance measures.