While AIDS is by far the main motivator for autologous donation
, the hysteria seems to be subsiding somewhat.
Cloud's autologous donation
program in a January 1985 MLD article.
Our autologous donation
procedure is outlined in Figure II.
But most surgical procedures are scheduled, if not elective, and then there is ample time for the autologous donation
Unlike these previous studies, the Phase 2 and 3 studies to be conducted by Double- Crane will be without autologous blood conservation procedures such as Acute Normovolemic Hemodilution (ANH) or Intraoperative Autologous Donation
(IAD) used in previous clinical studies.
At the time, the hospital, which for years had maintained its own donor center in addition to using the regional blood bank, was conducting an autologous donation
program as well as a directed-donor program for renal transplants.
All patients in the "re-do" study will undergo the same intraoperative autologous donation
(IAD) procedure, with either Hemolink(TM) or allogeneic red blood cells administered in response to transfusion triggers.
Although both groups initially underwent acute normovolemic hemodilution (ANH) to collect autologous (the patient's own) blood, only the Oxygent-treated patients were subjected to a second blood-harvesting step (referred to as intraoperative autologous donation
, or IAD).
Mazer will present an overview of recent data from Phase II and III CABG trials of Hemolink(TM) in conjunction with intraoperative autologous donation
The trial had two main purposes: first, to determine if Hemolink(TM) could be given safely in a large number of patients undergoing routine CABG surgery; and second, to determine whether the transfusion of donor red blood cells (RBCs) could be effectively avoided or reduced in patients administered Hemolink(TM) relative to patients in a control group, in concert with an effective blood conservation technique known as Intra-operative Autologous Donation
In surgical applications Hemolink(TM) is used in conjunction with a blood conservation strategy known as intra-operative autologous donation
Some 270 patients will be involved in the multinational trial in conjunction with a blood conservation strategy known as intraoperative autologous donation