autologous bone marrow transplantation


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to autologous bone marrow transplantation: Hematopoietic stem cell transplantation

autologous bone marrow transplantation

A procedure in which haematopoietic stem cells are extracted (apheresed) from a patient with lymphoma and other cancers, who is treated with high-dose chemo- and/or radiotherapy to eliminate malignant cells in the bone marrow. The stem cells are then administered. ABMT is a standard second-line therapy for some lymphomas; it has a low risk of infection and has no risk of graft-versus-host disease, which is typical of allogeneic bone marrow transplantation. ABMT is less preferred for patients with acute myeloid leukaemia, in whom the relapse may occur as the patient’s marrow may contain malignant cells.

autologous bone marrow transplantation

Transplantation medicine The administration to an individual 'X' of his/her own BM, often to a leukemic Pt in relapse who, because a suitable HLA-matched donor is not available, would otherwise die of the disease. See Bone marrow.

autologous bone marrow transplantation

Abbreviation: ABMT
The harvesting and preservation of a patient's own blood-forming cells, followed by their eventual reintroduction into a patient. The procedure may be used to treat a variety of cancers and blood disorders. Current practice is to mobilize stem cells into the blood stream with growth factors and then to collect and filter the blood by leukapheresis. In leukapheresis stem cells are identified by a cell surface antigen called CD34. After desirable blood-forming cells with this antigen are removed from the patient's blood, high-dose chemotherapy, monoclonal antibody therapy, or radiation may be used to purge the marrow of diseased cells. Healthy CD34+ cells capable of rebuilding the bone marrow are then returned to the patient and stimulated to reproduce. Synonym: autologous hematopoietic stem cell transplantation
See also: transplantation
References in periodicals archive ?
Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non-Hodgkin's lymphomas who are still responsive to conventional-dose therapy.
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy sensitive non Hodgkin's lymphoma.
Benefit of autologous bone marrow transplantation over sequential chemotherapy in poor-risk aggressive non-Hodgkin's lymphoma: updated results of the prospective study LNH87-2.
High dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma.
VACOP-B versus VACOP-B plus autologous bone marrow transplantation for advanced diffuse non-Hodgkin's lymphoma: results of a prospective randomized trial by the non-Hodgkin's lymphoma cooperative study group.
High-dose chemotherapy followed by autologous bone marrow transplantation versus dexamethasone, cisplatin and cytarabine in aggressive non-Hodgkin's lymphoma with partial response to front line chemotherapy: a prospective randomized Italian multicentre study.
Comparison of CHOP chemotherapy with autologous bone marrow transplantation for slowly responding patients with aggressive non-Hodgkin's lymphoma.
Autologous bone marrow transplantation in the treatment of malignant lymphoma and Hodgkin's disease.
Long term prolongation of disease free and overall survival following autologous bone marrow transplantation in patients with advanced relapsed follicular lymphoma.
Timing of high dose CBV and autologous bone marrow transplantation in the management of relapsed or refractory Hodgkin's disease.
Chopra R, McMillan A, Linch D, Yuklea S, Taghipour G, Pearc R, et al The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease.

Full browser ?