Remarkably, apocynin inhibited the TGF-[beta]1 induced ROS as well as the autoinduction
of TGF-[beta]1 gene expression.
Within the 3-day period between dosing and sacrifice, concentrations of all congeners increased linearly with the administered dose (Figure 1), which indicates an absence of autoinduction
of metabolism for the different dose levels within this time period.
Clearance may change when enzyme inducers or inhibitors are added to the medication, but the many published pharmacokinetic investigations of busulfan have not indicated nonlinear pharmacokinetics or autoinduction
causing a change in clearance over time.
Urist, Bone: Formation by Autoinduction
, Science, 12, 893899(1965).
Development of competence in Streptococcus pneumonaie: pheromone autoinduction
and control of quorum sensing by the oligopeptide permease.
Chronic oral administration of ATRA results in autoinduction
of ATRA metabolism by cytochrome P450-dependent enzymes, leading to progressive reduction in plasma ATRA concentrations, which may be the most important mechanism for development of resistance to therapy.
Specifically, women metabolize ethanol slightly faster than men (18 mg/dL/h compared to 16 mg/dL/h), (2) while chronic alcohol abusers have very high elimination rates (30 mg/dL/h to 40 mg/dL/h) due to autoinduction
of the metabolizing enzyme CYP2E1.
The communal buildup of AHLs triggers the production of more AHLs by individual bacteria, which keeps the process going--something called an autoinduction
1) Unfortunately, carbamazepine can be a difficult medication to use, due to significant drug-drug interactions, laborious titration related to enzyme autoinduction
(both due to induction of the cytochrome P450 system), potential for agranulocytosis and hyponatremia.
It was Urist' theory of autoinduction
which brought the term "bone morphogenetic protein" to light.
Because of its variable absorption, long half-life of 25- 65 hours and autoinduction
of metabolism, levels may fluctuate widely during trial dosing.
is caused by involvement of cytochrome P450 2136 but not 2C9.