autoimmune pancreatitis


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autoimmune pancreatitis

A condition characterised by diffuse enlargement of the pancreas and irregular stenosis of the main pancreatic duct (less commonly, also of the intrapancreatic bile duct on ERCP, associated with other autoimmune diseases).

Lab
Increased IgG4 autoantibodies.

Management
Corticosteroids.

autoimmune pancreatitis

Chronic pancreatitis, usually found in association with other autoimmune disorders (e.g., inflammatory bowel disease, rheumatoid arthritis, or Sjogren's syndrome). It is a relatively rare disease, suggested by the finding of antibodies against lactoferrin and carbonic anhydrase in the blood of affected patients. Biopsy specimens reveal infiltration of the organ by lymphocytes. It is treated with corticosteroids.
Synonym: autoimmune-related pancreatitis
See also: pancreatitis

autoimmune pancreatitis

Inflammation of the pancreas featuring an autoimmune process with obvious lymphocyte infiltration and fibrosis causing organ dysfunction. The disease takes a range of forms and includes conditions formerly known as chronic sclerosing pancreatitis, non-alcoholic duct-destructive chrinic pancreatitis, pseudotumerous pancreatitis and duct-narrowing chronic pancreatitis.
References in periodicals archive ?
Autoimmune pancreatitis is a chronic inflammatory disorder of unknown etiology associated with hypergammaglobulinemia that leads to fibrosis and organ dysfunction.
IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations.
Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease.
Strategy to differentiate autoimmune pancreatitis from pancreas cancer.
Their 18 cases of IgG4-associated fibroin-flammatory lesions included 6 patients with known autoimmune pancreatitis.
Clinical diagnostic criteria of autoimmune pancreatitis.
His clinical expertise and knowledge of pathology were instrumental in identifying novel pancreatic tumor types, that is, perivascular epithelioid cell tumor (PEComa) (clear cell "sugar" tumor) and acinar cystadenoma of the pancreas, and in defining inflammatory conditions of the pancreas such as autoimmune pancreatitis.
Paraduodenal pancreatitis (synonyms: groove pancreatitis, cystic dystrophy of the duodenal wall) and autoimmune pancreatitis deserve special attention in the differential diagnosis of PDAC.
Autoimmune pancreatitis represents a distinct and increasingly frequently detected form of CP with characteristic clinical, radiologic, and histologic features.
Autoimmune pancreatitis with evolution to cholangitis: a case report.

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