autoimmune hypothesis

autoimmune hypothesis

a concept that defects occur in the body's immune system as one ages. As a result of the defects, a person's antibody-producing cells can no longer distinguish between "self " and "nonself " tissues. The body's own cells are then misidentified as foreign and are attacked by antibodies. However, circumstantial evidence links autoimmune diseases to preceding infections.
References in periodicals archive ?
20th century research concentrated on the pathogenesis of vitiligo, its most convincing argument being the autoimmune hypothesis, sustained by the association of vitiligo with other autoimmune diseases (alopecia areata, autoimmune thyroiditism diabetis mellitus, etc.
The autoimmune hypothesis promulgates that it is the auto-antibodies that are responsible for schizophrenia and, according to the viral hypothesis, it may be the body's abnormal response to a slow viral infection or the undefeated viral antigens causing the schizophrenia pathology.
The occurrence of vitiligo with Addison's disease, alopecia areata, pernicious anemia, and Hashimoto's thyroiditis also favors the autoimmune hypothesis of the disease (3).
The autoimmune hypothesis is supported by the family history of vitiligo, association with other autoimmune disorders, presence of autoantibodies to melanocytes and positive response to immunosuppressive therapeutic agents.
There exit a number of theories to explain the aetiology of this disease, but the most accepted one is autoimmune hypothesis.
Full browser ?