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autoimmune hypothesis

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autoimmune hypothesis,
a concept that defects occur in the body's immune system as one ages. As a result of the defects, a person's antibody-producing cells can no longer distinguish between "self " and "nonself " tissues. The body's own cells are then misidentified as foreign and are attacked by antibodies. However, circumstantial evidence links autoimmune diseases to preceding infections.


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The autoimmune hypothesis of COPD is intriguing because most diseases conventionally considered to be autoimmune are more prevalent in women than in men and this represents an area for possible future research.
The results of Vernooy and colleagues that are reported in this issue of the AJRCCM (11) support this autoimmune hypothesis because of the increased staining of GrA in type II cells.
 
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