autoimmune haemolytic anaemia


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autoimmune haemolytic anaemia

A condition in which IgG autoantibodies are directed against a component of Rh factor coat red cell surfaces.
 
Aetiology
Idiopathic (±50%), SLE, CLL, lymphomas.
 
Clinical finding
Anaemia of rapid onset, fatigue with angina or CHF, jaundice, splenomegaly.
 
Lab
Anaemia, spherocytosis, nucleated RBCs, positive direct Coombs test.
 
Management
Prednisone, IV immune globulin, splenomegaly.
 
Prognosis
Good.
References in periodicals archive ?
Patients with a falling Hb on AZT (or AZT-containing regimen) should be investigated for other causes of anaemia, usually nutritional or infective, but autoimmune haemolytic anaemia should also be considered.
Red blood cell transfusion in warm-type autoimmune haemolytic anaemia.
Severe anaemia caused by human parvovirus B19 infection in a patient with autoimmune haemolytic anaemia and a B-cell non-Hodgkin lymphoma.
These are IgG- and IgM-mediated disorders that produce positive direct antiglobulin (Coombs') tests that are clinically and serologically indistinct from autoimmune haemolytic anaemia.

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