autoimmune haemolytic anaemia


Also found in: Encyclopedia.

autoimmune haemolytic anaemia

A condition in which IgG autoantibodies are directed against a component of Rh factor coat red cell surfaces.
 
Aetiology
Idiopathic (±50%), SLE, CLL, lymphomas.
 
Clinical finding
Anaemia of rapid onset, fatigue with angina or CHF, jaundice, splenomegaly.
 
Lab
Anaemia, spherocytosis, nucleated RBCs, positive direct Coombs test.
 
Management
Prednisone, IV immune globulin, splenomegaly.
 
Prognosis
Good.
References in periodicals archive ?
We describe a 9-year-old boy with warm autoimmune haemolytic anaemia resistant to the standard treatment who was successfully treated with Rituximab.
Autoimmune haemolytic anaemia (AIHA) is an acquired clinical condition characterised by the production of antibodies that bind to the surface of circulating erythrocytes, leading to haemolysis, and shortened red blood cell (RBC) survival with elimination by the reticuloendothelial system.
Patients with a falling Hb on AZT (or AZT-containing regimen) should be investigated for other causes of anaemia, usually nutritional or infective, but autoimmune haemolytic anaemia should also be considered.
Red blood cell transfusion in warm-type autoimmune haemolytic anaemia.
Anaemia and HIV-infection Decreased production Increased loss and/or destruction Deficiencies Haemolysis Erythropoietin Autoimmune haemolytic anaemia Iron Thrombotic thrombocytopaenic Folate purpura (TTP) Vitamin [B.
High-dose intravenous immunoglobulin in the management of autoimmune haemolytic anaemia complicating thalassemia major.
Approach to anaemia in HIV Reduced red cell production Increased red cell loss Related to HIV Related to HIV Infection Haemolysis HIV itself, mycobacteriae, TTP, autoimmune haemolytic anaemia parvovirus, fungi Malignancy Blood loss High-grade NHL, HL Gastrointestinal, high-grade NHL, Kaposi sarcoma, infection (CMV, Drugs Candida) Zidovudine, co-trimoxazole, isoniazid Hypersplenism Anaemia of chronic disease Infection, lymphoma Unrelated to HIV Unrelated to HIV Haematinic deficiencies Haemolysis Iron, vitamin [B.
Adult Onset Still\'s Disease with Autoimmune Haemolytic anaemia is a rare combination, difficult to diagnose but easy to manage.
Keywords: Adult Onset Still's disease, Autoimmune Haemolytic anaemia, AOSD, Yamaguchi criteria, Methylprednisolone, Pakistan.

Full browser ?