autoimmune haemolytic anaemia
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autoimmune haemolytic anaemiaA condition in which IgG autoantibodies are directed against a component of Rh factor coat red cell surfaces.
Idiopathic (±50%), SLE, CLL, lymphomas.
Anaemia of rapid onset, fatigue with angina or CHF, jaundice, splenomegaly.
Anaemia, spherocytosis, nucleated RBCs, positive direct Coombs test.
Prednisone, IV immune globulin, splenomegaly.