autoimmune gastritis

(redirected from autoimmune atrophic gastritis)

autoimmune gastritis

A rare form of chronic atrophic gastritis, which is most common in African Americans and northern Europeans, characterised by autoimmune destruction of fundic and body glands.

Lab
Serum antiparietal and anti-intrinsic factor antibodies that cause IF deficiency, decreasing available cobalamin, often linked to megaloblastic anaemia
References in periodicals archive ?
It causes reversible megaloblastic anemia and the most frequent cause of severe vitamin B12 deficiency is the loss of the intrinsic factor in autoimmune atrophic gastritis.
The loss of intrinsic factor caused by autoimmune atrophic gastritis ("pernicious anemia") is one of the most frequent causes of severe vitamin B12 deficiency [5, 6].
High levels of B12 could also be explained, to some extent, by either one of innate errors (hereditary enzymatic disorders), autoimmune atrophic gastritis, neoplastic disorders of the digestive tract or some myelodysplastic syndromes.
Correlate pernicious anemia with autoimmune atrophic gastritis.
RELATED ARTICLE: Autoimmune atrophic gastritis leads the way to pernicious anemia
Recent evidence suggests that H pylori can trigger the development of autoimmune atrophic gastritis through a process of molecular mimicry in which the bacterial organisms take on the antigenic appearance of parietal cells.
In autoimmune atrophic gastritis, autoant-bodies cause destruction of the parietal cell mass that makes up the gastric mucosa.
Autoimmune atrophic gastritis is the most frequent cause of pernicious anemia in temperate climates.
Autoimmune atrophic gastritis typically causes symptoms related to vitamin B12 (cobalmin) deficiency, including anemia, gastrointestinal symptoms, and neurologic symptoms, including dementia.
Patients with autoimmune atrophic gastritis have high levels of antiparietal and anti-intrinsic factor antibodies (types 1 and 2 antibodies to intrinsic factor).