autocrine


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Related to autocrine: endocrine, Autocrine signaling

autocrine

 [aw´to-krin]
denoting a mode of hormone action in which a hormone binds to receptors on and affects the function of the same cell that produced it.

au·to·crine

(aw'tō-krin),
Denoting self-stimulation through cellular production of a factor and a specific receptor for it.
[auto- + G. krinō, to separate]

autocrine

/au·to·crine/ (-krin) denoting a mode of hormone action in which a hormone binds to receptors on and affects the function of the cell type that produced it.

autocrine

(ô′tō-krĭn′)
adj.
Relating to the release of chemical substances from endocrine cells that bind to receptors on the same cell that produces them.

autocrine

[ô′təkrin]
denoting the effect of a hormone on cells that produce it.

autocrine

adjective Referring to a substance (e.g., a growth factor) produced by a cell which stimulates its own secretion.

au·to·crine

(aw'tō-krin)
Denoting self-stimulation through cellular production of a factor and a specific receptor for it.
[auto- + G. krinō, to separate]

autocrine

1. Of a substance secreted by a cell and released into the extracellular fluid, that then acts on the cell.
2. Of a cell responding to such chemical messengers.

autocrine (ˑ·tō·krin),

adj affecting the cells of origin, used in describing glandular and hormonal action.
References in periodicals archive ?
It is also present in the endothelial cells and SMCs and operates through autocrine and paracrine ways.
Thus, BAT was shown to release factors such as IGF-1, fibroblast growth factor-2, IL-1[alpha], IL-6, bone morphogenetic protein-8b, and lipocalin prostaglandin D synthase that primarily have autocrine or paracrine actions (Villarroya et al.
Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.
Cytokines are small soluble proteins produced by a cell that alter the behavior or properties of another cell locally or systemically in an autocrine or paracrine manner.
While none of these molecules actually signal as a gas, their hydrophilicity and lipophilicity enable them to readily traverse intracellular compartments where they serve in a variety of autocrine and paracrine signals capacities.
PDGF signaling in tumor cells induces point mutations, amplification, and translocations, which stimulate autocrine stimulatory loops [6, 21].
Hewison M: Vitamin D and immune function: autocrine, paracrine or endocrine?
21] Accordingly, G-CSF treatment improved spatial learning and reacquisition of information in rats engaged in a radial maze, presumably, by promoting the survival of new neurons, [22] which suggests an autocrine protective signaling mechanism that can improve memory in elderly people.
9 The exact role of autocrine, paracrine and endocrine factors responsible for endometrial receptivity is yet to be explored.
Neovascularization in prostate carcinoma develops not only through cell-to-cell interaction, but also via multiple autocrine, paracrine and mechanical factors, and is similar to the one seen in the wound repair process [8-12].
Resistance mechanisms include constitutive autocrine signaling through EGFR or loss of the full-length BRAF V600E protein.