autocrine


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Related to autocrine: endocrine, Autocrine signaling

autocrine

 [aw´to-krin]
denoting a mode of hormone action in which a hormone binds to receptors on and affects the function of the same cell that produced it.

au·to·crine

(aw'tō-krin),
Denoting self-stimulation through cellular production of a factor and a specific receptor for it.
[auto- + G. krinō, to separate]

autocrine

/au·to·crine/ (-krin) denoting a mode of hormone action in which a hormone binds to receptors on and affects the function of the cell type that produced it.

autocrine

(ô′tō-krĭn′)
adj.
Relating to the release of chemical substances from endocrine cells that bind to receptors on the same cell that produces them.

autocrine

[ô′təkrin]
denoting the effect of a hormone on cells that produce it.

autocrine

adjective Referring to a substance (e.g., a growth factor) produced by a cell which stimulates its own secretion.

au·to·crine

(aw'tō-krin)
Denoting self-stimulation through cellular production of a factor and a specific receptor for it.
[auto- + G. krinō, to separate]

autocrine

1. Of a substance secreted by a cell and released into the extracellular fluid, that then acts on the cell.
2. Of a cell responding to such chemical messengers.

autocrine (ˑ·tō·krin),

adj affecting the cells of origin, used in describing glandular and hormonal action.
References in periodicals archive ?
4,12) In addition, Ang II receptors have also been found in numerous tissues, allowing for autocrine and paracrine signaling systems.
The induction of ligand protein expression in these death receptor signal pathways likely results in the formation of autocrine loops, as shown in Fig.
Few assays recreate the sequential process of collagen adhesion followed by the release of autocrine factors.
The intrathymic environment is characterized by a complex network of paracrine, autocrine, and endocrine signals involving both interleukins and thymic peptides, which can be envisioned to operate in a synergistic network to carry the evolving T cell through its stepwise development to a mature T cell.
It has been shown that VEGF-A induces proliferation, survival, and protection of AML cells against apoptosis by an autocrine loop via VEGFR signaling (31), (32), (33).
Th2 type cytokines, such as IL-10, are anti-inflammatory cytokines, and act as autocrine inhibitors of cytotrophoblast invasion in the uterine wall.
Functional studies in cell lines and animal models will be necessary to determine whether CTGF acts in an autocrine or paracrine manner on gallbladder tumor initiation and progression.
In the present work, prostate MECs under normal culture conditions secreted high levels of IL-6, consistent with stimulation of autocrine IL-6 loops, conferring oncogenic properties (Rojas a al.
Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.
To complement use of serum free media, research has been focused on the development of cell lines that are cabaple of autocrine growth of cells in culture, rendering the reduced cost (of not having to supply serum as sources of IGF) (Sunstrom et al.
Prostanoid end products, formed as described above, act through families of discrete G protein-linked surface receptors and transporters and exert diverse effects on cellular processes both in an autocrine and paracrine fashion.