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autoimmunity
(redirected from Autoantigens)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
autoimmunity /au·to·im·mu·ni·ty/ (-ĭ-mu´nĭ-te) a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body's own tissues (autoantigens); it may result in hypersensitivity reactions or, if severe, in autoimmune disease.
Autoimmunity
A condition in which the body's immune system produces antibodies in response to its own tissues or blood components instead of foreign particles or microorganisms.
Mentioned in: AIDS, Hypoparathyroidism

autoimmunity
[-imyo̅o̅′nitē]
an abnormal condition in which the body reacts against constituents of its own tissues. Autoimmunity may result in hypersensitivity and autoimmune disease. Also called acute immune disease. See also antibody-specific model, autoantibody, autoantigen, autoimmune disease.

autoimmunity [aw″to-ĭ-mu´nĭ-te]
a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body's own tissues (autoantigens); it may result in hypersensitivity reactions or, if severe, in autoimmune disease.

autoimmunity,
n abnormal immune response where the body attacks its own tissue constituents. Also called
acute immune disease.

autoimmunity
a condition which may result in autoimmune disease.

autoimmunity
Self immunity Immunology The reaction of an organism's immune system to self antigens as if they were non-self or foreign; like alloimmunity, autoimmunity is characterized by the activation of T cells, clonal expansion, and antibody production. See Anti-nuclear antibodies, Anti-receptor antibodies, Clonal anergy, Superantigen.


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Methods: Immortalized human salivary acinar cell line NS-SV-AC cells were incubated with EGCG (epigallocat-echin-3 gallate), the most abundant GTP, prior to determination of expression changes in major autoantigens by microarray, RT-PCR and Western analysis.
The peptide, now called MBP8298, targets a particular stretch of amino acids of human myelin basic protein (MBP), a major structural protein of myelin that is one of the candidate autoantigens in MS.
The reacting IgG class antibody, which was purified from normal human serum by affinity chromatography on bupleuran 2IIc (a pharmacologically active pectic polysaccharide from the roots of Bupleurum falcatum)-immobilized Sepharose, showed cross-reactivity not only with some other pharmacologically active pectic polysaccharides from other medicinal herbs but also with autoantigens such as single-strand DNA, myosin and tublin from mammals.
 
 
 
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