autoantigen


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autoantigen

 [aw″to-an´tĭ-jen]
an antigen that, despite being a normal tissue constituent, is the target of a humoral or cell-mediated immune response, such as in autoimmune disease.

au·to·an·ti·gen

(aw'to-an'ti-jen),
A "self" antigen; any tissue constituent that evokes an immune response by the host.

autoantigen

/au·to·an·ti·gen/ (-an´tĭ-jen) an antigen that despite being a normal tissue constituent is the target of a humoral or cell-mediated immune response, as in autoimmune disease.

autoantigen

(ô′tō-ăn′tĭ-jən)
n.
An endogenous antigen that stimulates autoantibody production, as in an autoimmune reaction.

autoantigen

[ô′tō·an′tijin]
Etymology: Gk, autos + anti, against, genein, to produce
an endogenous body constituent that stimulates the production of autoantibodies and an autoimmune reaction. An autoantigen associated with Addison's disease has been identified as the enzyme 17 α-hydroxylase. Also called self-antigen. See also antibody-specific model, autoantibody, autoimmune disease.

autoantigen

Any of an organism’s own antigens (self-antigens)—e.g., glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies.

autoantigen

Immunology Any self antigen–eg, glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies. See Antigen.

au·to·an·ti·gen

(aw'to-an'ti-jĕn)
A "self" antigen; any tissue constituent that evokes an immune response by the host.

autoantigen

a tissue constituent that stimulates production of autoantibodies or self-reactive T lymphocytes in the animal in which it occurs.
References in periodicals archive ?
It is well known that several autoantigens able to induce autoimmunity have also the potential to induce antigenspecific tolerance depending upon the route, the dose, and the physical form of the antigen [11].
However in patients of DH epidermal transglutaminase (eTG) appears to be the dominant autoantigen as it colocalizes with IgA deposition in the skin.
Autoantibody Autoantigen ICA The ICA autoantigens are not well defined but include a sialoglycoconjugate and glutamic acid decarboxylase (34) 1AA Insulin (proinsulin antibodies have also been demonstrated) GADA Glutamic acid decarboxylase (GAD65 > GAD67) 1A-2A A protein tyrosine phosphatase (PTP) ZnT8A Zinc transporter-8 that transports zinc into insulin secretory granules ICA = lslet cell cytoplasmic autoantibodies; IAA = Insulin autoantibodies; GADA = Glutamic acid decarboxylase autoantibodies; 1A-2A = Insulinoma associated-2 autoantibodies; ZnT8A = Zinc trasnporter-8 autoantibodies Table 1.
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.
Peterson, Hong Wang and Xiao-Fen Yang, "Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes," Journal of Allergy and Clinical Immunology, vol.
Autoantigens defined by experimental serum and B-cell analysis in RA syndromes in animals and humans (10) Type/nature Specificity Autoantigen Citrulline-containing peptide Keratin Perinuclear factor Savoy antigen Filaggrin Human leukocyte antigen Calpastatin Immunoglobulin (rheumatoid factor) Calreticulin Antineutrophil cytoplasmic antigen Antinuclear antibody Immunoglobulin heavy-chain protein / p68 Heteronuclear ribonucleoprotein A2 (RA33) Glucose-6-phosphate isomerase Cartilage (organ Collagen type II specific) Chondrocyte antigen 65 Large aggregating chondroitin sulfate proteoglycan (aggrecan) Human chondrocyte glycoprotein 39 Cartilage oligomeric matrix protein Non-autoantigens Bacterial heat shock protein
An attempt will be made to see the possible involvement of Mycobacterial protein antigen(s) acting as an alternate autoantigen for autoimmune disorders by employing various techniques such as SDS-PAGE, direct binding and competition ELISA.
Molecular architecture of the goodpasture autoantigen in anti-GBM nephritis.
Desmoglein 3 protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.
Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).
A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen.
Laminin gamma-1 is a major autoantigen in anti-p-200 pemphigoid.