autoantigen


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Related to autoantigen: autoimmune disease, alloantigen, Autoantibodies

autoantigen

 [aw″to-an´tĭ-jen]
an antigen that, despite being a normal tissue constituent, is the target of a humoral or cell-mediated immune response, such as in autoimmune disease.

au·to·an·ti·gen

(aw'to-an'ti-jen),
A "self" antigen; any tissue constituent that evokes an immune response by the host.

autoantigen

/au·to·an·ti·gen/ (-an´tĭ-jen) an antigen that despite being a normal tissue constituent is the target of a humoral or cell-mediated immune response, as in autoimmune disease.

autoantigen

(ô′tō-ăn′tĭ-jən)
n.
An endogenous antigen that stimulates autoantibody production, as in an autoimmune reaction.

autoantigen

[ô′tō·an′tijin]
Etymology: Gk, autos + anti, against, genein, to produce
an endogenous body constituent that stimulates the production of autoantibodies and an autoimmune reaction. An autoantigen associated with Addison's disease has been identified as the enzyme 17 α-hydroxylase. Also called self-antigen. See also antibody-specific model, autoantibody, autoimmune disease.

autoantigen

Any of an organism’s own antigens (self-antigens)—e.g., glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies.

autoantigen

Immunology Any self antigen–eg, glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies. See Antigen.

au·to·an·ti·gen

(aw'to-an'ti-jĕn)
A "self" antigen; any tissue constituent that evokes an immune response by the host.

autoantigen

a tissue constituent that stimulates production of autoantibodies or self-reactive T lymphocytes in the animal in which it occurs.
References in periodicals archive ?
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
In this technique phages expressing candidate autoantigens are immunoprecipitated with antibodies in the patient sample and identified by high-throughput DNA sequencing (19).
Identification of tissue transglutaminase as the autoantigen of celiac disease.
Sardy M, Karpati S, Merkl B, Paulsson M, Smyth N: Epidermal transglutaminase (Tgase 3) is the autoantigen of dermatitis herpetiformis.
The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis.
Signals of seminal vesicle autoantigen suppresses bovine serum albumin-induced capacitation in mouse sperm.
11) In a subsequent study, 56% of patients with acquired hypoparathyroidism and autoimmune polyglandular syndrome 1 had autoantibodies directed against the extracellular portion of the parathyroid calcium-sensing receptor (CaSR), the autoantigen now suggested to cause parathyroid failure.
University of North Carolina at Chapel Hill researchers, however, have discovered that patients with autoimmune disease harbor antibodies reactive to a normal "self" protein (the autoantigen of this disease), as well as to its mirror image protein.
The T cell erroneously marks the autoantigen as being pathogenic, initiating a cascade that induces destruction of the non-regenerative insulin-producing beta cells of the pancreas.
Binding of immunoglobulin G from patients with autoimmune thyroid disease to rat sodium-iodide symporter peptides: Evidence for the iodide transporter as an autoantigen.
ATX-MS-1467 consists of four synthetic peptides that mimic naturally occurring peptides derived from human Myelin Basic Protein (MBP), a key autoantigen in multiple sclerosis.
Type II collagen is the major protein in articular cartilage and is a potential autoantigen in this disease.