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autacoid

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au·ta·coid or au·to·coid t-koid)
n.
An organic substance, such as a hormone, produced in one part of an organism and transported by the blood or lymph to another part of the organism where it exerts a physiologic effect on that part.

autacoid
[ô′təkoid]
any one of the substances produced locally by one group of cells that exerts effects on other types of cells in the same region.

autacoid
a term once proposed to replace the term hormone and recently suggested as a general term for various physiologically active, endogenous substances (histamine, serotonin, angiotensin, prostaglandins, etc.) that do not yet fit into existing functional classifications.

autacoid
Endocrinology A locally acting hormone-like substance–eg, histamine, serotonin, angiotensin, eicosanoids


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We speculate that HVPC alters the permeability of these microvessels by somehow prohibiting individual endothelial cells from actively or passively changing their shape from flat to more rounded, as they typically do under the influence of inflammatory mediators such as histamine, serotonin, bradykinin, and other autacoids released after injury.
 
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