much greater than] aurothioglucose, aurothiomalate
, and auranofin) compared with Gpx and glutathione reductase (Nordberg and Arner 2001).
The drug, aurothiomalate, is being tested in a phase I clinical trial in patients with lung cancer at Mayo Clinic's sites in Minnesota and Arizona.
Based on findings to date, a phase II clinical trial is being planned to combine aurothiomalate with agents targeted at other molecules involved in cancer growth.
Murray stressed that this new study has not tested aurothiomalate against pancreatic cancer yet, but any treatment that targets this major cancer pathway offers a new avenue for therapy.
Smith and Levander to test two gold-containing compounds, aurothiomalate and aurothioglucose.
Smith saw similar pathological trends in the mice he injected with aurothiomalate but not in the animals given aurothioglucose.
The study also shows that an agent, aurothiomalate, being tested at Mayo Clinic in a phase I clinical trial substantially inhibits growth of these cancer stem cells.
We show that aurothiomalate, the agent now being tested in lung cancer patients, can, in fact, target these cells," he added.
While aurothiomalate was once used to treat rheumatoid arthritis, the researchers have now discovered that it can also target PKCiota.
Currently, the agent is being tested in patients at Mayo Clinic's sites in Minnesota and Arizona and, based on this phase I trial, a phase II human clinical trial is planned to combine aurothiomalate with agents targeted at other molecules involved in cancer growth.
Subjects were excluded if they were < 25 years of age (n = 11); had diabetes mellitus (n = 4); reported long-term use of glucocorticoids (n = 11), thiazide diuretics (n = 7), methotrexate (n = 1), or sodium aurothiomalate
(n = 1); were currently pregnant (n = 4); or used effective equipment for removing uranium from well water (n = 4).
Persons with diabetes mellitus (n = 4) or chronic use of methotrexate (n = 1) or sodium aurothiomalate
(n = 1), pregnant women (n = 4), and households with effective equipment for removing uranium from well water (n = 4) were excluded.