auranofin


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auranofin

 [aw-ran´o-fin]
a gold-containing compound that is a disease-modifying antirheumatic drug used to treat active rheumatoid arthritis, usually that not adequately controlled by nonsteroidal antiinflammatory drugs, or nondrug therapy such as physical therapy; administered orally.

auranofin

/au·ran·o·fin/ (aw-ran´ah-fin) a gold-containing compound used in the treatment of active rheumatoid arthritis.

auranofin

(ô-răn′ə-fĭn)
n.
A gold-containing compound used to treat rheumatoid arthritis.

auranofin

[ôr′ənof′in]
an oral gold disease-modifying antirheumatoid drug.
indications It can be prescribed for the treatment of rheumatoid arthritis, but is generally not first line therapy.
contraindications Auranofin is contraindicated for patients who have disorders that are caused by or aggravated by medicines containing gold or who have impaired kidney function.
adverse effects Among the most severe adverse effects are diarrhea, loose stools, abdominal pain, nausea, vomiting, rash, pruritus, stomatitis, anemia, leukopenia, granulocytopenia, thrombocytopenia, eosinophilia, proteinemia, hematuria, and elevated liver enzyme levels.

auranofin

A gold preparation that can be taken by mouth for the treatment of RHEUMATOID ARTHRITIS. A brand name is Ridaura.

auranofin (ôran´əfin),

n brand name: Ridaura;
drug class: gold salt;
action: specific antiinflammatory action unknown;
uses: rheumatoid arthritis.

auranofin

a compound containing 29% gold; used orally in chrysotherapy in dogs and cats.
References in periodicals archive ?
We will carry out a clinical trial with collaborators in Cameroon and the UK to determine whether Auranofin, an FDA approved drug, can be repurposed as a macrofilaricide to kill adult worms.
Chelating agents, such as penicillamine (Cuprimine[R]) and gold compounds, such as auranofin (Ridaura[R]) are used to decrease inflammation and to slow the destruction of joint tissue.
hydroxychloroquine), 23 for auranofin, 29 for injectable gold, 7 for MTX, 19 for d-penicillamine, 6 for sulfasalazine, and 22 for placebo.
Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension.
Using a high-throughput screen for drugs developed by them, a collaborative group of scientists from UC San Diego School of Medicine, UC San Francisco and Wake Forest School of Medicine discovered that auranofin - a drug approved by the US Food and Drug Administration 25 years ago for rheumatoid arthritis - is very effective in targeting an enzyme that protects amebae from oxygen attack (thus enhancing sensitivity of the amebae to reactive oxygen-mediated killing).
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation.
mansoni, auranofin killed nearly two-thirds of the worms.
The only other disease-modifying antirheumatic drugs that have been evaluated for the treatment of ankylosing spondylitis in randomized, placebo-controlled trials are penicillamine (19) and auranofin, (18) and neither were effective.
All patients were treated with nonsteroidal anti-inflammatory drugs or disease-modifying antirheumatic drugs, including gold thiomalate, auranofin, D-penicillamine, or bucillamine.
Understanding specific metal-protein interactions has been one of the key issues of this symposium and was central in Frank Shaw's (EDU) talk on the applications of gold complexes and the pivotal role of auranofin as anti-arthritic drug.
In addition, it offers SORAFIN, a proprietary platform technology for the treatment of skin diseases, which is a combination of auranofin combined with a corticosteroid.