The defining histologic features of dysplastic colorectal epithelium in IBD are analogous to those of sporadic adenomatous polyps and include (1) nuclear atypism
manifested by increased nuclear to cytoplasmic ratios, crowding, and hyperchromasia; (2) cytoplasmic abnormalities suggesting altered differentiation and clonality, such as diminished or, conversely, excessive goblet cell mucin; and (3) abnormal growth patterns indicating faulty control of cellular proliferation, including glandular crowding, tubular or villiform architecture and the absence of normal base-to-surface epithelial maturation.
6,7) However, because the incidence of nonleukemic dermatoses in leukemia patients is significantly higher than that of LC, it is difficult to make a specific diagnosis of LC when only a few leukemic infiltrates are present or leukemic cells display little atypism
In the study by Page et al, (3) papillary apocrine change lesions were confined to those cases that lacked nuclear atypism
1,2) Mitoses may be found, especially in areas of higher cellularity, but atypism
does not occur in benign lesions.
There was no nuclear enlargement, nuclear atypism
, immunoblasts, or serpiginous necrosis.
25] Bowen disease and squamous cell carcinoma arising in Bowen disease demonstrate a more pronounced atypism
of keratinocytes, dyskeratosis, and a severe architectural effacement.