atypical squamous cells of undetermined significance


Also found in: Acronyms.

atypical squamous cells of undetermined significance (ASCUS),

the term in the Bethesda system for reporting cervical/vaginal cytologic diagnosis describing cellular abnormalities that are more marked than those attributable to reactive changes but that quantitatively or qualitatively fall short of a definitive diagnosis of low-grade squamous intraepithelial lesion; may reflect a benign or a potentially serious lesion.
See also: Bethesda system, reactive changes.

a·typ·i·cal squa·mous cells of un·de·ter·mined sig·nif·i·cance

(ASCUS) (ā-tip'i-kăl skwā'mŭs sel zŭn-dĕ-tĕr'mind sig-nif'i-kăns)
The term in the Bethesda system for reporting cervical-vaginal cytologic diagnosis describing cellular abnormalities that are more marked than those attributable to reactive changes but that quantitatively or qualitatively fall short of a definitive diagnosis of squamous intraepithelial lesion (SIL); may reflect a benign or a potentially serious lesion.
See also: Bethesda system, reactive changes
References in periodicals archive ?
Evaluation of p16 immunostaining to predict high-grade cervical intraepithelial neoplasia in women with Pap results of atypical squamous cells of undetermined significance.
Results of a randomized trial on the management of cytology interpretation of atypical squamous cells of undetermined significance.
Although detection of atypical squamous cells of undetermined significance (ASCUS) was unchanged with the thin-layer method, it should be evaluated in overall detection of ASCUS and squamous intrae pithelial lesions (SIL) by comparing the ASCUS:STL ratio using the 2 methods.
2) Atypical Squamous Cells of Undetermined Significance (ASC-US) - cases with no definitive cellular abnormality but enough suspicion to keep the case from being considered "normal" (this is an ambiguous category)
Out of 27 cases of epithelial cell abnormality are of atypical squamous cells of undetermined significance (ASCUS) (17), atypical glandular cells of undetermined significance (AGCUS) (1), low-grade squamous intraepithelial lesion (LSIL) (2), high-grade squamous intraepithelial lesion (HSIL) (2) and invasive carcinoma cervix (5).
Results of the Atypical Squamous Cells of Undetermined Significance (ASCUS) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study established the role of high-risk HPV (HR-HPV) testing as a cost-effective triage strategy for atypical squamous lesions and led to development of the 2001 American Society for Colposcopy and Cervical Pathology (ASCCP) management guidelines.
8%) cases showed atypical squamous cells of undetermined significance (ASCUS) and four (3.
The guidelines confirm that the HPV test is an appropriate tool in the management of atypical squamous cells of undetermined significance (ASC-US) among women 21 years and older and as a cotest with the Pap for women who are 30 years and older.
One woman with persistent HPV in this middle-age group developed atypical squamous cells of undetermined significance (ASCUS).
The two types of samples retrieved had similar sensitivity and specificity for both atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions (see box).

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