atypical squamous cells of uncertain significance


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atypical squamous cells of uncertain significance

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ASC-US

An abnormal finding on a Papanicolaou test in which squamous cells from the endocervix have enlarged nuclei with irregular nuclear membranes and hyperchromasia. These pathological changes are more prominent than those typically seen with inflammation alone. ASC-US is often associated with infection of the cervix with human papillomavirus. In some cases the abnormality resolves on its own; in others, it is associated with higher-grade lesions of the uterine cervix.
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