atypical fibroxanthoma

Also found in: Acronyms.

a·typ·i·cal fi·bro·xan·tho·ma

a solitary, often ulcerated, small, cutaneous, usually benign tumor composed of foamy histiocytes, spindle cells, and bizarre giant cells; usually found on the exposed skin of older people; microscopically, atypical fibroxanthoma closely resembles malignant fibrous histiocytoma, but originates in the dermis.

atypical fibroxanthoma

A cutaneous tumour seen in the head and neck of older individuals, which is linked to sun exposure and radiation therapy. It is characterised by a proliferation of spindle cells, many of which have bizarre and hyperchromatic nuclei, increased mitoses and atypical mitotic figures.
References in periodicals archive ?
CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker.
Some investigators concluded that the distinction between spindle cell squamous carcinoma and atypical fibroxanthoma was of little prognostic significance.
Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions: a clinicopathologic and immunohistochemical study of 21 cases.
Atypical fibroxanthoma of the skin: a clinicopathologic study of 140 cases.
Atypical fibroxanthoma of the skin metastatic to a lung: report of a case, features by conventional and electron microscopy, and a review of relevant literature.

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