atypical endometrial hyperplasia

atypical endometrial hyperplasia

a particularly severe form of hyperplasia marked by an increase in the number of glands; these glands have little stroma separating them, yet retain an orderly architecture, a trait that distinguishes them from adenocarcinoma; sometimes referred to as endometrial cancer in situ.

a·typ·i·cal en·do·me·tri·al hy·per·pla·si·a

(ā-tip'i-kăl en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, which have little, if any, stroma separating them but retain an orderly architecture distinguishing them from adenocarcinoma.
References in periodicals archive ?
Among them, 29 cases were atypical endometrial hyperplasia (11 cases) or carcinoma (18 cases) confirmed by histology evaluation.
13%] was endometrial polyp with atypical endometrial hyperplasia [Table 3].
This is the case of women affected by PCOS that show a high risk of developing atypical endometrial hyperplasia (EH), which is considered a precancerous lesion, which may progress to EC.
In one study 16 out of 17 patients diagnosed as having atypical endometrial hyperplasia showed regression of the lesion with progestin therapy and concluded that treatment of atypical hyperplasia and well- differentiated carcinoma of the endometrium with progestins appears to be a safe alternative to hysterectomy in women under the age of 40.
Between 1996 and 2009, the scientists enrolled 20 women with atypical endometrial hyperplasia and 14 women with early and well-defined endometrial cancer.
1993) with a diameter exceeding 3 cm for which preoperative treatment with GnRH agonists is indicated (Romer 1998); (2) the use hormonal therapies in the previous 6 months (including the drugs of the study); (3) atypical endometrial hyperplasia (at biopsy); (4) uterine and/or concomitant adnexal pathologies (including malignancy); (5) cardiovascular, hepatic, or renal impairment; and (6) any medical condition that might be worsened by the treatment.
Expression of the retinoblastoma-related gene Rb2/p130 is down-regulated in atypical endometrial hyperplasia and adenocarcinoma.
Treatment of nonatypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system.
Invasive adenocarcinoma was found at hysterectomy in more than 40% of patients who had been diagnosed with atypical endometrial hyperplasia (AEH) at specialized centers of the Gynecology Oncology Group, shocking study investigators who had intended to explore more conservative treatment options for women diagnosed with the condition.
Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.
Significance of concurrent endometrial cancer in women with a preoperative diagnosis of atypical endometrial hyperplasia.
Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome.
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