atypical endometrial hyperplasia

atypical endometrial hyperplasia

a particularly severe form of hyperplasia marked by an increase in the number of glands; these glands have little stroma separating them, yet retain an orderly architecture, a trait that distinguishes them from adenocarcinoma; sometimes referred to as endometrial cancer in situ.

a·typ·i·cal en·do·me·tri·al hy·per·pla·si·a

(ā-tip'i-kăl en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, which have little, if any, stroma separating them but retain an orderly architecture distinguishing them from adenocarcinoma.
References in periodicals archive ?
Between 1996 and 2009, the scientists enrolled 20 women with atypical endometrial hyperplasia and 14 women with early and well-defined endometrial cancer.
Nineteen of the 20 women with atypical endometrial hyperplasia (95 percent) experienced a complete response, meaning that a biopsy taken after treatment showed normal endometrium.
1993) with a diameter exceeding 3 cm for which preoperative treatment with GnRH agonists is indicated (Romer 1998); (2) the use hormonal therapies in the previous 6 months (including the drugs of the study); (3) atypical endometrial hyperplasia (at biopsy); (4) uterine and/or concomitant adnexal pathologies (including malignancy); (5) cardiovascular, hepatic, or renal impairment; and (6) any medical condition that might be worsened by the treatment.
Atypical glandular cell Pap test results also detected 5 cases of precancerous complex atypical endometrial hyperplasia.
Expression of the retinoblastoma-related gene Rb2/p130 is down-regulated in atypical endometrial hyperplasia and adenocarcinoma.
Invasive adenocarcinoma was found at hysterectomy in more than 40% of patients who had been diagnosed with atypical endometrial hyperplasia (AEH) at specialized centers of the Gynecology Oncology Group, shocking study investigators who had intended to explore more conservative treatment options for women diagnosed with the condition.
Prevalence of underlying adenocarcinoma in women with atypical endometrial hyperplasia.
094([dagger]) Atypical endometrial hyperplasia 10 15.
Three cases of atypical endometrial hyperplasia showed patchy staining, whereas most of the adenocarcinomas that were positive for p53 showed strong and diffuse immunoreactivity throughout the tumor.
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