atypical Spitz nevus

atypical Spitz nevus

A Spitz-nevus-like tumour of the skin with one or more atypical features, for which prudent pathologists would recommend close followup.

Spitz nevus features—classical vs atypical
• Size—< 10 mm vs > 10 mm.
• Symmetry—Symmetrical vs Asymmetrical.
• Lateral borders—Sharply demarcated vs Poorly demarcated.
• Deep border—Rounded, pushing vs Infiltrative.
• Cellularity—Variable vs Clustered cells in dermis.
• Irregular nesting—Rare vs Common.
• Deep extension—Rare vs Common.
• Expansile nodule—Rare vs Common.
• Deep mitoses—Rare vs Common.
• Ulceration—Rare vs Variable.
• Maturation/zonation—Common vs Rare.
• Kamino bodies—Common vs Rare.
References in periodicals archive ?
Variants of Spitz nevus Variants Reference Angiomatoid Spitz nevus (a) 2, 3 Atypical pigmented spindle cell nevus (b) 4, 5 Atypical Spitz nevus (c) 4, 5 Desmoplastic Spitz nevus (d) 6, 7 Hyalinizing Spitz nevus (e) 1 Malignant Spitz nevus (f) 5, 8 Pagetoid Spitz nevus 5, 9 Pigmented spindle cell nevus 4, 10, 11 Recurrent Spitz nevus 12 Spitz nevus with florid pseudoepithelial 13 hyperplasia Spitz nevus with halo phenomenon 14 Tubular epithelioid cell nevus (g) 15 (a) Several investigators consider angiomatoid Spitz nevus to be a variant of desmoplastic Spitz nevus.
As discussed above, PEM is a prototypical example of melanocytoma and atypical Spitz nevus and, perhaps, atypical deep-penetrating tumors are additional candidates.
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