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ATTRACTAnti-TNF Trial in Rheumatoid Arthritis with cA2 (Chimeric monoclonal antibody) infliximab Treatment. A trial comparing the effects of humanised anti-TNF cA2 (infliximab/Remicade) + methotrexate (MTX) to MTX alone on the progression of rheumatoid arthritis.
Conclusions It works; infliximab patients had retardation or arrest of their rheumatoid arthritis; and improvement (in 39% to 54% of patients) of joint space narrowing and bone erosion, vs progressive damage in control patients treated with MTX alone.