Atropine

atropine /at·ro·pine/ (at´ro-pen) an anticholinergicand antispasmodic alkaloid used as the sulfate salt to relax smooth muscles and increase and regulate the heart rate by blocking the vagus nerve, and to act as a preanesthetic antisialagogue, an antidote for various toxic and anticholinesterase agents and as an antisecretory, mydriatic, and cycloplegic.

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at·ro·pine (tr-pn, -pn) or at·ro·pin (-pn)

n.

An alkaloid obtained from belladonna and related plants, used to dilate the pupils of the eyes and as an antispasmodic, antisudorific, and anticholinergic.

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Atropine

A poisonous alkaloid obtained from belladonna or related plants, used medically to dilate the pupils of the eyes and to stop spasms.

Mentioned in: Fugu Poisoning

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atropine (at´rōpēn),

n an alkaloid that annuls parasympathetic effects and antagonizes the effects of pilocarpine. It acts directly on the effector cells, preventing the action but not the liberation of acetylcholine. It suppresses sweat and other glandular sections.

atropine sulfate,

n brand name: Sal-Tropine;
drug class: anticholinergic;
action: inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites;
uses: reduction of salivary and bronchial secretions.

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atropine

an anticholinergic alkaloid occurring in belladonna, hyoscyamus and stramonium. It acts as a competitive antagonist of acetylcholine at muscarinic receptors, blocking stimulation of muscles and glands by parasympathetic and cholinergic sympathetic nerves; used as a smooth muscle relaxant, as a preanesthetic to reduce secretions, and as an antidote to organophosphate poisoning. Has been used as a spasmolytic in many cases of gut hypermotility, e.g. equine spasmodic colic. Has the disadvantage of causing prolonged pupillary dilatation.

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atropine challenge test

used in the diagnosis of narcolepsy in dogs; pretreatment with atropine reduces the number of cataleptic attacks with exposure to food.

atropine methobromide

a synthetic muscarinic blocking agent used as a smooth muscle relaxant but less effective against poisoning with organophosphorus insecticides than atropine. Called also methylatropine.

atropine poisoning

severe toxic reaction due to overdosage of atropine. Signs include dilated pupils, absent pupillary light reflex, dry mouth, high heart rate, excitement, muscle tremor. In animals usually results from atropine overdose.

atropine sulfate

the pharmaceutical preparation in common use.

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atropine Therapeutics A racemic mixture of toxic alkaloids extracted from Atropa belladonna, a competitive antagonist of anticholinergics Effects Tachycardia, ↓ salivation, GI motility–constipation, sweating, cycloplegia, mydriasis, urinary retention, bronchodilation Therapeutic use Bronchodilator, reverses effects of organophosphate pesticides, nerve gases Contraindications Narrow-angle glaucoma, synechiae between iris and lens, GI obstruction, obstructive uropathy, megacolon, GERD, unstable cardiovascular disease and acute hemorrhage, tachycardia, myasthenia gravis