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a form of chronic inflammation or repeated episodes of acute inflammation in which the continued or recurrent proliferation of fibroblasts results in the formation of fibrous tissue that eventually contracts and leads to compression and atrophy of parenchymal tissue.
Synonym(s): fibroid inflammation
a localized protective response elicited by injury or destruction of tissues, which serves to destroy, dilute, or wall off both the injurious agent and the injured tissue.
The inflammatory response can be provoked by physical, chemical and biological agents, including mechanical trauma, exposure to excessive amounts of sunlight, x-rays and radioactive materials, corrosive chemicals, extremes of heat and cold, and infectious agents such as bacteria, viruses and other pathogenic microorganisms. Although these infectious agents can produce inflammation, infection and inflammation are not synonymous.
The classic signs of inflammation are heat, redness, swelling, pain and loss of function. These are manifestations of the physiological changes that occur during the inflammatory process. The three major components of this process are: (1) changes in the caliber of blood vessels and the rate of blood flow through them (hemodynamic changes); (2) increased capillary permeability; and (3) leukocytic exudation.
inflammation, usually of sudden onset, marked by the classic signs of heat, redness, swelling, pain and loss of function, and in which vascular and exudative processes predominate.
promotes adhesion of adjacent surfaces.
one that causes atrophy and deformity.
a form affecting mainly a mucous surface, marked by a copious discharge of mucus and epithelial debris.
prolonged and persistent inflammation marked chiefly by new connective tissue formation; it may be a continuation of an acute form or a prolonged low-grade form.
chronic inflammation bowel disease of sheep
a syndrome of unknown etiology, manifest with wasting, ill thrift and mortality or culling for poor production. Reported in England and Canada, it affects both housed and pastured sheep, predominantly in their first year of life, but cases up to three years-of-age have been seen. Affected sheep are dull and anorectic with pale mucous membranes and have fecal staining of the perineum. The rumen fill is reduced and the feces are soft and malodorous. Blood examination shows hypoalbuminemia, an elevated blood urea nitrogen and leukocytosis with neutrophilia. On postmortem there is a lymphocytic enteritis with gross thickening of segments or the entire or distal part of the small intestine. There is no evidence for Johne's disease or parasitic gastroenteritis and the syndrome has similarities to the proliferative enteropathies of swine and horses.
a homogeneous layer of exudate lying close to but detached from the underlying inflamed tissue, which is comparatively unharmed; may form a fibrinous cast.
manifested by the development of a fibrinous exudate which is firmly attached to the underlying tissue, such that it cannot be removed except by tearing off a superficial layer.
one in which the prominent feature is an exudate.
one marked by an exudate of coagulated fibrin.
leads to the development of fibrous tissue.
a form, usually chronic, attended by formation of granulomas.
leads to the development of new connective tissue.
leading to the enlargement of the affected tissues.
inflammation affecting chiefly the stroma of an organ.
inflammation within a vessel or viscus leading to occlusion of the lumen.
inflammation affecting chiefly the essential tissue elements of an organ.
productive inflammation, proliferative inflammation
one leading to the production of new connective tissue fibers.
an acute inflammatory response to a powerful necrotizing toxin, e.g. Fusobacterium necrophorum toxin, characterized by formation on a mucosal surface of a false membrane composed of precipitated fibrin, necrotic epithelium and inflammatory leukocytes. See also diphtheritic inflammation (above).
one producing a serous exudate.
one due to a particular microorganism.
systemic inflammation response syndrome (SIRS)
a generalized inflammatory response with vasodilation of capillaries and postcapillary venules, increased permeability of capillaries, and hypovolemia. Depressed cardiac function and decreased organ perfusion follow. The various initiating stimuli include sepsis and septic shock, hyperthermia, pancreatitis, trauma, snake bite and immune-mediated diseases.
one due to a poison, e.g. a bacterial product.
one that follows a wound or injury.
that in which necrosis on or near the surface leads to loss of tissue and creation of a local defect or ulcer.