atovaquone


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atovaquone

 [ah-to´vah-kwōn]
an antibiotic used in treatment of mild to moderate Pneumocystis cariniipneumonia and the prevention and treatment of falciparum malaria; administered orally.

atovaquone

/ato·va·quone/ (ah-to´vah-kwōn) an antibiotic used in treatment of mild to moderate pneumonia and the prophylaxis and treatment of falciparum malaria.

atovaquone

(ə-tō′və-kwōn′)
n.
A drug, C22H19ClO3, used to treat pneumonia caused by pneumocystis fungi and, in combination with proguanil, to prevent or treat malaria.

atovaquone

[ah-to′vah-kwōn]
an antibiotic used in treatment of mild to moderate Pneumocystis pneumonia and the prevention and treatment of falciparum malaria. It is administered orally.

atovaquone

An agent used for treating mild to moderate Pneumocystis jiroveci (carinii) pneumonia in patients with HIV infection, and for salvage treatment of toxoplasmosis and microsporidiosis.
 
Pros
Less toxic, more tolerable than trimethoprim-sulfamethoxazole (TMP-SMX).

Cons
Less effective than TMP-SMX.
 
Adverse effects
Headache, nausea, diarrhoea, fever, rashes.

atovaquone

Mepron Infectious disease An agent used for treating PCP in Pts with HIV infection and for toxoplasmosis and microsporidiosis Pros Less toxic, more tolerable than T-S Cons Less effective than T-S Adverse effects Headache, nausea, diarrhea, fever and rashes. See AIDS, Pneumocystis cariniipneumonia, Trimethoprim–Sulfamethoxazole.

Atovaquone

A drug used in the treatment of MALARIA and TOXOPLASMOSIS. Brand names are Wellvone and, in combination with proguanil, Malarone.

atovaquone (ətō´vəkōn´),

n brand name: Mepron;
drug class: antipneumocystic;
action: unknown, may inhibit synthesis of ATP and nucleic acids;
uses: treatment of
Pneumocystis jiroveci (carinii) pneumonia in patients who are intolerant of trimethoprim-sulfamethoxazole.

atovaquone

a hydroxynaphthoquinone effective against protozoa; has been used in dogs to treat Pneumocystis infections and Toxoplasma tissue cysts.
References in periodicals archive ?
0-3 h] was also performed with 0-3-h postinvasion ring-stage parasites exposed for 6 h to atovaquone (3 [micro]mol/L) or amodiaquine (0.
Some patients are extremely sensitive to the atovaquone and they do not have an allergy.
The data and the resulting findings concerning the mode of action of atovaquone could lead to improved medications against the tropical disease.
Based on IMS Health sales data for the 12 month period ending Sept 2012, Atovaquone Proguanil garnered sales of Euro 20.
Antimalarial First reported Difference drug Introduced resistance (Years) Quinine 1632 1910 278 Chloroquine 1945 1957 12 Proguanil 1948 1949 1 Sulphadoxine- Pyremethamine 1967 1967 0 Mefloquine 1977 1981 5 Atovaquone 1996 1996 0 Table II.
The hydroxynaphthoquinone atovaquone identified as an antimalarial (Hudson 1985) in the early 1980s has proved to be highly effective in clinical trials but has to be used in combination with proguanil (as Malarone) to prevent the development of resistance (Srivastava 1999).
Atovaquone has also been used in combination with proquanil hydrochloride for the treatment of acute Plasmodium falciparum malaria in children (Ana-bwani et al.
For patients who are allergic to sulfa drugs, either dapsone, inhaled pentamidine or atovaquone can be used for Pneumocystis jiroveci pneumonia prophylaxis.
Malarone, a newly marketed combination of proguanil and atovaquone, offers the advantage of few side effects and a convenient weekly dosing schedule.
If the patient has an allergy to sulfa drugs, alternative regimens include intravenous pentamidine, trimethoprim and dapsone, clindamycin and primaquine, or atovaquone and trimetrexate.
Malarone is a combination of atovaquone and proguanil.
Each tablet contains 250 mg of atovaquone and 100 mg of proguanil, but a lower-dose tablet is available for children under 88 pounds.