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atorvastatin calcium

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a·tor·va·stat·in calcium (-tôrv-sttn)
n.
A statin drug used to treat hyperlipidemia.

atorvastatin calcium

Lipitor

Pharmacologic class: HMG-CoA reductase inhibitor

Therapeutic class: Lipid-lowering agent

Pregnancy risk category X

Action

Inhibits HMG-CoA reductase, which catalyzes first step in cholesterol synthesis; this action reduces concentrations of serum cholesterol and low-density lipoproteins (LDLs), linked to increased risk of coronary artery disease (CAD). Also moderately increases concentration of high-density lipoproteins (HDLs), associated with decreased risk of CAD.

Availability

Tablets: 10 mg, 20 mg, 40 mg, 80 mg

Indications and dosages

Adjunct to diet for controlling LDL, total cholesterol, apo-lipoprotein B, and triglyceride levels and to increase HDL levels in patients with primary hypercholesterolemia and mixed dyslipidemia; primary dysbetalipoproteinemia in patients unresponsive to diet alone; adjunct to diet to reduce elevated triglyceride levels

Adults: Initially, 10 mg P.O. daily; increase to 80 mg P.O. daily if needed. Adjust dosage according to patient's cholesterol level.

Adjunct to other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia

Adults: 10 to 80 mg P.O. daily

Adjunct to diet to decrease total cholesterol, LDL, and apo-lipoprotein B levels in boys and postmenarchal girls ages 10 to 17 with familial and nonfamilial heterozygous hypercholesterolemia

Boys and girls: Initially, 10 mg P.O. daily; adjust dosage upward or downward based on lipid levels. Maximum dosage is 20 mg daily.

Prevention of cardiovascular disease in patients without clinically evident coronary heart disease (CHD) but with multiple CHD risk factors

Adults: 10 mg P.O. daily

Prevention of stroke and myocardial infarction in patients with type 2 diabetes who have multiple riskfactors for CHD but without clinically evident CHD

Adults: Dosage individualized according to patient characteristics, such as goal of therapy and response according to National Cholesterol Education Program guidelines

Contraindications

• Hypersensitivity to drug or its components
• Active hepatic disease or unexplained, persistent serum transaminase elevations
• Pregnancy or breastfeeding

Precautions

Use cautiously in:
• renal impairment, hypotension, uncontrolled seizures, myopathy, alcoholism
• severe metabolic, endocrine, or electrolyte disorders
• women of childbearing age
• children younger than age 18.

Administration

• Give with or without food.
• Don't give with grapefruit juice or antacids.

RouteOnsetPeakDuration
P.O.Unknown1-2 hrUnknown

Adverse reactions

CNS: amnesia, abnormal dreams, emotional lability, headache, hyperactivity, poor coordination, malaise, paresthesia, peripheral neuropathy, drowsiness, syncope, weakness

CV: orthostatic hypotension, palpitations, phlebitis, vasodilation, arrhythmias

EENT: amblyopia, altered refraction, glaucoma, eye hemorrhage, dry eyes, hearing loss, tinnitus, epistaxis, sinusitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal cramps, abdominal or biliary pain, colitis, indigestion, dyspepsia, flatulence, stomach ulcers, gastroenteritis, melena, tenesmus, glossitis, mouth sores, dry mouth, dysphagia, esophagitis, pancreatitis, rectal hemorrhage

GU: hematuria, nocturia, dysuria, urinary frequency or urgency, urinary retention, cystitis, nephritis, renal calculi, abnormal ejaculation, decreased libido, erectile dysfunction, epididymitis

Hematologic: anemia, thrombocytopenia

Hepatic: jaundice, hepatic failure, hepatitis

Metabolic: hyperglycemia, hypoglycemia

Musculoskeletal: bursitis, joint pain, back pain, leg cramps, gout, muscle pain or aches, myositis, myasthenia gravis, neck rigidity, torticollis, rhabdomyolysis

Respiratory: dyspnea, pneumonia, bronchitis

Skin: alopecia, acne, contact dermatitis, eczema, dry skin, pruritus, rash, urticaria, skin ulcers, seborrhea, photosensitivity, diaphoresis, toxic epidermal necrolysis

Other: taste loss, gingival bleeding, fever, facial paralysis, facial or generalized edema, flulike symptoms, infection, appetite changes, weight gain, allergic reaction, Stevens-Johnson syndrome

Interactions

Drug-drug. Antacids, colestipol: decreased atorvastatin blood level

Azole antifungals, cyclosporine, erythromycin, fibric acid derivatives, niacin, other HMG-CoA inhibitors: increased risk of myopathy

Digoxin: increased digoxin level, greater risk of toxicity

Hormonal contraceptives: increased estrogen level

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, creatine kinase: increased levels

Drug-food. Grapefruit juice: increased drug blood level, greater risk of adverse effects

Drug-herbs. Red yeast rice: increased risk of adverse effects

Patient monitoring

• Monitor patient for signs and symptoms of allergic response.
Evaluate for muscle weakness (a symptom of myositis and possibly rhabdomyolysis).
• Monitor liver function test results and blood lipid levels.

Patient teaching

• Tell patient he may take drug with or without food.
Advise patient to immediately report allergic response, irregular heart beats, unusual bruising or bleeding, unusual tiredness, yellowing of skin or eyes, or muscle weakness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision.
• Inform patient taking hormonal contraceptives that drug increases estrogen levels. Instruct her to tell all prescribers she's taking drug.
• Tell men that drug may cause erectile dysfunction and abnormal ejaculation. Encourage them to discuss these issues with prescriber.
• Tell patient he'll undergo regular blood testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above.



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