atorvastatin


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Related to atorvastatin: Rosuvastatin, Ramipril, simvastatin, atorvastatin calcium

atorvastatin

 [ah-tor″vah-stat´in]
an agent that inhibits cholesterol synthesis, used as the calcium salt in treatment of primary hypercholesterolemia and hyperlipidemia; administered orally.

atorvastatin

/ator·va·stat·in/ (ah-tor″vah-stat´in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the calcium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia.

atorvastatin

(ə-tôr′və-stăt′n)
n.
A statin, (C33H34FN2O5)2Ca·3H2O, that blocks the body's synthesis of cholesterol and is used to treat hyperlipidemia.

atorvastatin

an antihyperlipidemic.
indications This drug is used to lower the levels of both cholesterol and triglycerides in the plasma.
contraindications Known hypersensitivity, pregnancy, lactation, and active liver disease prohibit the use of this drug.
adverse effects Liver dysfunction is a potentially life-threatening side effect of this drug. Other adverse effects include rash, pruritus, alopecia, dyspepsia, flatus, pancreatitis, lens opacities, myalgia, and headache.

atorvastatin

A cholesterol-lowering HMG-CoA reductase inhibitor, or statin, which improves the lipid profile—LDL-C reduced 35% to 60%; TGs reduced 20–37%; HDL-C increased 5–9%.
 
Adverse effects
Liver dysfunction, rhabdomyolysis with acute renal failure secondary to myoglobinuria, constipation, flatulence, dyspepsia, abdominal pain, myalgia, weakness.
 
Indications
Homozygous familial hypercholesterolaemia, severe refractory hypercholesterolaemia.

atorvastatin

Lipitor® Cardiology A cholesterol-lowering HMG-CoA reductase inhibitor or statin which improves the lipid profile–↓ 35% to 60% LDL-C; ↓TGs 20–37%;↑ 5–9% HDL-C Adverse effects Liver dysfunction, rhabdomyolysis with acute renal failure 2º to myoglobinuria, constipation, flatulence, dyspepsia, abdominal pain, myalgia, weakness. See AVERT, Statin.

atorvastatin

A cholesterol-lowering drug. A brand name is Lipitor. See STATINS.
References in periodicals archive ?
Patients had been randomized to treatment with atorvastatin 40 mg/day or placebo for the primary prevention of cardiovascular events and the median follow-up was 2.
All study participants had an FDG-PET scan when the study began and after 1 year of atorvastatin or placebo to measure changes in inflammation of the aorta, the main artery coming out of the heart (Figure 1).
emblica 500 mg, or atorvastatin 10 mg produced significant reductions in the reflection index, suggesting improvement in endothelial function after 12 weeks of treatment compared with baseline.
Compared with pravastatin, treatment with higher potency statins, especially atorvastatin and simvastatin, might be associated with an increased risk of new-onset diabetes.
Ranbaxy decided to stop making atorvastatin until the company has thoroughly investigated the cause of the contamination and remedied the problem," the US agency said.
the lots of atorvastatin, packaged in bottles of 90 and 500 tablets, are being recalled due to possible contamination with very small glass particles similar to the size of a grain of sand.
4] + atorvastatin (5 mg/kg) treated livers there was pronounced fatty changes in the centers of the hepatic lobules and lymphocellular infiltrations in the periportal fields.
The researchers noted that their findings with atorvastatin suggest that understanding the mechanism by which statins affect immune markers may identify new approaches for the management of HIV infection.
Nonetheless, to help ensure that atorvastatin was not interfering with the vitamin D method, we analyzed a 100-mg/L solution of atorvastatin (at least 1000 times the concentrations encountered in plasma for patients taking standard doses of atorvastatin) with no corresponding mass fragments being seen.
Keywords: Total saponins of "panax notoginseng root" Atorvastatin Vascular smooth muscle cell Proliferating cell nuclear antigen Cyclind [D.
In 2004, the family doctor of one of the authors (DG) reported that he had contacted the manufacturer of atorvastatin to request information on atorvastatin-associated memory impairment.
In that well-designed study, they indicated that alternate-day dosing of atorvastatin causes a significant lipid-lowering and antiinflammatory effects similar to that of daily administration and it may provide some cost savings (1).