atorvastatin


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atorvastatin

 [ah-tor″vah-stat´in]
an agent that inhibits cholesterol synthesis, used as the calcium salt in treatment of primary hypercholesterolemia and hyperlipidemia; administered orally.

atorvastatin

/ator·va·stat·in/ (ah-tor″vah-stat´in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the calcium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia.

atorvastatin

(ə-tôr′və-stăt′n)
n.
A statin, (C33H34FN2O5)2Ca·3H2O, that blocks the body's synthesis of cholesterol and is used to treat hyperlipidemia.

atorvastatin

an antihyperlipidemic.
indications This drug is used to lower the levels of both cholesterol and triglycerides in the plasma.
contraindications Known hypersensitivity, pregnancy, lactation, and active liver disease prohibit the use of this drug.
adverse effects Liver dysfunction is a potentially life-threatening side effect of this drug. Other adverse effects include rash, pruritus, alopecia, dyspepsia, flatus, pancreatitis, lens opacities, myalgia, and headache.

atorvastatin

A cholesterol-lowering HMG-CoA reductase inhibitor, or statin, which improves the lipid profile—LDL-C reduced 35% to 60%; TGs reduced 20–37%; HDL-C increased 5–9%.
 
Adverse effects
Liver dysfunction, rhabdomyolysis with acute renal failure secondary to myoglobinuria, constipation, flatulence, dyspepsia, abdominal pain, myalgia, weakness.
 
Indications
Homozygous familial hypercholesterolaemia, severe refractory hypercholesterolaemia.

atorvastatin

Lipitor® Cardiology A cholesterol-lowering HMG-CoA reductase inhibitor or statin which improves the lipid profile–↓ 35% to 60% LDL-C; ↓TGs 20–37%;↑ 5–9% HDL-C Adverse effects Liver dysfunction, rhabdomyolysis with acute renal failure 2º to myoglobinuria, constipation, flatulence, dyspepsia, abdominal pain, myalgia, weakness. See AVERT, Statin.

atorvastatin

A cholesterol-lowering drug. A brand name is Lipitor. See STATINS.
References in periodicals archive ?
Conclusion: Atorvastatin used as an adjuvant therapy with currently existing standard therapy (topical betamethasone) in patients having mild to moderate plaque type psoriasis reduces disease severity and cardiovascular risks.
Hence, the present study had been designed for exploring the analgesic potential of atorvastatin and simvastatin in Wistar rats, which may widen the therapeutic horizon for the said agents.
Calibration curves were made for atorvastatin and internal standard from concentration time data, values for time to achieve maximum plasma concentration.
Despite no significant difference reported for OLE supplementation compared to atorvastatin groups, the small numbers in each arm limit the ability to interpret this.
The investigators compared atorvastatin monotherapy against atorvastatin plus ezetimibe in 246 adults who underwent PCI under intravascular ultrasound guidance at 17 centers.
Patients had been randomized to treatment with atorvastatin 40 mg/day or placebo for the primary prevention of cardiovascular events and the median follow-up was 2.
All study participants had an FDG-PET scan when the study began and after 1 year of atorvastatin or placebo to measure changes in inflammation of the aorta, the main artery coming out of the heart (Figure 1).
To identify all the relative literature involving the use of atorvastatin in the Chinese population, we conducted a systemic search in PubMed with the following keywords: "atorvastatin" (Supplementary concept) or "atorvastatin" (All field) and ("China" [AD] or "China" [all field] or "Chinese" [All field]).
43; Vanderbilt University, Nashville, TN, USA) utilizing data from a previous parallel design study examining changes in PWV following treatment for 6 mo with atorvastatin 10 mg/d or placebo [7].
emblica 500 mg, or atorvastatin 10 mg produced significant reductions in the reflection index, suggesting improvement in endothelial function after 12 weeks of treatment compared with baseline.
Compared with pravastatin, there was an increased risk of incident diabetes with atorvastatin (adjusted hazard ratio 1.
The FDA found in late November that the risk of injury from taking Atorvastatin was low, and users should continue to take the drug unless otherwise instructed by their doctors.