atopy


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atopy

 [at´o-pe]
a clinical hypersensitivity state or allergy with a hereditary predisposition; the tendency to develop an allergy is inherited, although the specific clinical form (such as hay fever or asthma) is not. The antibody reagin is involved. Called also atopic, hereditary, or spontaneous allergy.

at·o·py

(at'ō-pē),
A genetically determined state of hypersensitivity to environmental allergens. Type I allergic reaction is associated with the IgE antibody and a group of diseases, principally asthma, hay fever, and atopic dermatitis.
[G. atopia, strangeness, fr. a- priv. + topos, a place]

atopy

/at·o·py/ (at´ah-pe) a genetic predisposition toward the development of immediate hypersensitivity reactions against common environmental antigens (atopic allergy), most commonly manifested as allergic rhinitis but also as bronchial asthma, atopic dermatitis, or food allergy.

atopy

See atopic.

atopy

A state of increased sensitivity to common antigens (e.g., house dust, animal dander, pollen) with increased production of allergen-specific IgE. Atopy may have a hereditary component, given the increased susceptibility to hay fever, asthma and eczematoid dermatitis.

atopy

Clinical immunology A state of ↑ sensitivity to common antigens–eg, house dust, animal dander, pollen, with ↑ production of allergen-specific IgE; atopy may have a hereditary component as there is ↑ susceptibility to hay fever, asthma, and eczematoid dermatitis. See Asthma, Atopic dermatitis, Hay fever.

at·o·py

(at'ŏ-pē)
A genetically determined state of hypersensitivity to environmental allergens. Type I allergic reaction is associated with the IgE antibody and a group of diseases, principally asthma, hay fever, and atopic dermatitis.
[G. atopia, strangeness, fr. a- priv. + topos, a place]

atopy

A state giving rise to an allergy in which the reaction occurs at a different site from that of contact with the causal ALLERGEN. Atopy is an immediate hypersensitivity reaction associated with IMMUNOGLOBULIN E (IgE) and is a maternally transmitted genetic disorder due to mutations in a gene on chromosome 11. This gene codes for the IgE receptor on MAST CELLS. Atopy causes a proneness to ASTHMA, HAY FEVER and ECZEMA (atopic DERMATITIS). The term is derived from the Greek a , not and topos , a place.

Atopy

A state that makes persons more likely to develop allergic reactions of any type, including the inflammation and airway narrowing typical of asthma.
Mentioned in: Asthma

atopy

type 1 allergic reaction, induced in susceptible individuals by pollens, foods, animal dander and venoms (Table 1)
Table 1: Classification of types of hypersensitivity reactions
Type IType IIType IIIType IVType V
AntigenPollens, moulds, mites, drugs, foods, parasitesCell surface moietiesBacteria, fungi, parasitesCell or tissue moietiesCell surface receptors
MediatorsIgE and mast cellsIgG, IgM, complementIgG, IgM, IgA, complementT-cell-activated macrophages and lymphokinesIgG
TestsSkin tests (wheal and flare)Coombs' test
Red cell agglutination
Antibody precipitation
Immune complexesSkin test (erythema, induration)Indirect immunofluorescence
Time to reaction5-10 minutes6-36 hours4-12 hours48-72 hoursVariable
HistologyOedema, vasodilatation, mast cell deregulation, eosinophilsTarget cell damageAcute inflammation, neutrophils, vasculitisPerivascular inflammation, mononuclear cells, granuloma, caseation and necrosis in TBNormal or hypertrophy
Characteristic diseasesExtrinsic asthma, atopic eczema, allergic rhinitis, anaphylaxisHaemolytic anaemia, transfusion reactions, HDN, Goodpasture's syndrome, addisonian pernicious anaemia, myasthenia gravisAutoimmune disease (RA, SLE, glomerulonephritis)
Low-grade persistent infection (viral hepatitis)
Environmental diseases (farmer's lung)
Pulmonary TB, contact dermatitis, graft-versus-host disease, insect bites, Hansen's diseaseGraves, disease, myasthenia gravis
TreatmentAntigen avoidance
Topical corticosteroids
Sodium cromoglicate
Exchange transfusion, plasmapheresis, immunosuppressivesCorticosteroids, immunosuppressives, plasmapheresisImmunosuppressives, cortico-steroids, antigen removalTreatment of presenting disease

Ig, immunoglobulin; TB, tuberculosis; HDN, haemolytic disease of the newborn; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.

at·o·py

(at'ŏ-pē)
A genetically determined state of hypersensitivity to environmental allergens.
[G. atopia, strangeness, fr. a- priv. + topos, a place]

atopy (ā´tōpē),

n (atopic hypersensitivity, “spontaneous” clinical allergy), a group of “allergic” disorders showing a marked familial distribution; although the susceptibility appears to be inherited, contact with the antigen must occur before hypersensitivity can develop. Disorders include asthma or hay fever resulting from pollens and gastrointestinal tract and skin reactions resulting from food.

atopy

a clinical syndrome involving type I hypersensitivity (allergy) with a hereditary predisposition. Immunoglobulin E (IgE) is involved.

canine atopy
characterized by pruritus, often seasonal, mainly of feet, face and ventral body, with self-trauma. Secondary pyoderma, hyperhidrosis and otitis externa are often present. Rhinitis, conjunctivitis or gastrointestinal disorders may also occur.
References in periodicals archive ?
Atopy is a risk factor for respiratory symptoms in COPD patients: Results from the EUROSCOP study.
However, it is known that respiratory distress in the postnatal period including mainly TTN is an independent risk factor for a diagnosis of asthma in childhood; atopy is observed more frequently in children who had been diagnosed as having TTN with the impact of genetic predisposition, and respiratory function tests are most frequently affected by asthma (16).
This protective effect of breast milk in the prevention of atopy may be attributable to several possible mechanisms.
are more prone for the disease, and a personal and family history of atopy has a predisposing role.
Animals with milder or seasonal atopy may benefit from antihistamines or supplements with balanced omega-3 and omega-6 fatty acids.
Whether present or not in the Japanese, the pun on the word atopy can be linked to Ito's larger critique of common metaphors, especially in US immigration discourse, that cast immigrants as diseased people, animals, invasive plants, or even objects of war.
To define maternal atopy, each mother was tested with a panel of allergens: Alternaria alternata, cat hair, dog epithelium, house dust mites, German cockroach, Cladosporium sp.
Atopy can progress into an itch-scratch-itch cycle with hair loss, scabs, crusts, and secondary bacterial skin infection.
CD14-dependent airway neutrophil response to inhaled LPS: role of atopy.
Procedures: At the time of patients' entry into the study the clinical characteristics including age gender onset age asthma duration smoking history family history regular corticosteroid inhalation hospitalization history and presence of atopy were documented according to a detailed structured questionnaire.
Lack of association between IgA deficiency and respiratory atopy in young male adults.
In the Palmer study, no protective effect against development of atopy was seen as a result of early exposure to raw egg.