atmospheric pressure chemical ionisation

atmospheric pressure chemical ionisation

A method of mass spectrometry ionisation in which an aerosolised sample is sprayed at atmospheric pressure into a heated region where a metal pin held at a high electric potential sustains a corona discharge. The solvent discharge creates reagent ions that react with neutral sample molecules, resulting in protonated ions which then pass through a sampling aperture into the spectrometer’s mass analyser.
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Current ionisation methods: The use of 18 specified ionisation methods in mass spectrometry, namely atmospheric pressure chemical ionisation (APCI), atmospheric pressure photoionisation (APPI), chemical ionisation (CI), desorption chemical ionisation (DCI), desorption/ionisation on silicon (DIOS), direct analysis in real time (DART), electron ionisation (EI), electrospray ionisation (ESI), fast atom bombardment (FAB), field desorption (FD), field ionisation (FI), glow discharge (GD), inductively coupled plasma (ICP), ion attachment ionisation (IAI), matrix-assisted laser desorption ionisation (MALDI), negative ion electron capture (NIEC), thermal ionisation (TI), thermospray or other (more than 30 ionisation methods were identified in this market study).
The instrument must be capable of electrospray and atmospheric pressure chemical ionisation analyses.
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