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atherogenic |
Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson | 0.02 sec. |
atherogenic adjective Referring to the ability to initiate or accelerate atherogenesis—the deposition of atheromas, lipids, and calcium in the arterial lumen How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Increased visceral fat is associated with further deposition of fat in the liver and muscle, causing local tissue insulin resistance, as well as a rise in circulating factors that are atherogenic and thrombogenic (eg, free fatty acids, tumor necrosis factor-[alpha] [TNF-[alpha]], interleukin-6 [IL-6], and plasminogen activator inhibitor type-1 [PAI-1]), and a decline in factors linked to insulin sensitivity (eg, adiponectin, leptin). A positive correlation of C-reactive protein (CRP) and coronary artery disease, which could be explained by the atherogenic effects of chronic inflammation, is well known (Beck et al. Coronary artery calcification, atherogenic lipid changes, and increased erythrocyte volume in black injection drug users infected with human immunodeficiency virus-1 treated with protease inhibitors. |
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