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atherogenesis

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
atherogenesis /ath·ero·gen·e·sis/ (-jen´ĕ-sis) formation of atheromatous lesions in arterial walls.atherogen´ic
ath·er·o·gen·e·sis (th-r-jn-ss)
n.
Formation of atheromatous deposits, especially on the innermost layer of arterial walls.
atherogenesis
Etymology: Gk, athere, porridge, oma, tumor, genein, to produce
the formation of subintimal plaques in the lining of arteries. atherogenic, adj.
atherogenesis
formation of atheromas in arterial walls.


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Macrophages play a key role in atherogenesis by releasing proinflammatory cytokines and forming foam cells in subendothelial lesions.
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The earliest lesions of atherogenesis consist of arterial intimal accumulations of foam cells (primarily lipid-laden macrophages) and T lymphocytes intermixed with smooth muscle cells (7).
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