panhypopituitarism

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panhypopituitarism

 [pan-hi″po-pĭ-too´ĭ-tar-izm″]
generalized hypopituitarism due to absence of or damage to the pituitary gland; in its complete form it leads to absence of gonadal function, loss of secondary sex characters, and insufficiency of thyroid and adrenal function. When cachexia is a prominent feature, it is called simmonds' disease.

pan·hy·po·pi·tu·i·tar·ism (PHP),

(pan-hī'pō-pi-tū'i-tăr-izm), [MIM*312000]
A state in which the secretion of all anterior pituitary hormones is inadequate or absent; caused by a variety of disorders that result in destruction or loss of function of all or most of the anterior pituitary gland. Rare forms of PHP are inherited as autosomal recessive [MIM*262600] or as X-linked recessive [MIM*312000].

panhypopituitarism

/pan·hy·po·pi·tu·i·ta·rism/ (pan″hi″po-pĭ-too´ĭ-tah-rizm) generalized hypopituitarism due to absence or damage of the pituitary gland, which, in its complete form, leads to absence of gonadal function and insufficiency of thyroid and adrenal function. When cachexia is a prominent feature, it is called Simmonds' disease or pituitary cachexia.

panhypopituitarism

[panhī′pōpito̅o̅′itəriz′əm]
Etymology: Gk, pan + hypo, under, pituita, phlegm
generalized insufficiency of pituitary hormones, resulting from damage to or deficiency of the gland. Prepubertal panhypopituitarism, a rare disorder usually associated with a suprasellar cyst or craniopharyngioma, is characterized by dwarfism with normal body proportions, subnormal sexual development, and insufficient thyroid and adrenal function. Diabetes insipidus is frequently present, bitemporal hemianopia or complete blindness may occur, and skin is often yellow and wrinkled, but mentality is usually unimpaired. X-ray films show delayed fusion of the epiphyses, suprasellar calcification, and, frequently, destruction of the sella turcica. The condition is treated with cortisone, thyroid and sex hormone replacement, and human growth hormone. Postpubertal panhypopituitarism may be caused by postpartum pituitary necrosis (Sheehan's syndrome) resulting from thrombosis of pituitary circulation during or after delivery or other trauma to the pituitary. Characteristic signs of the disorder are failure to lactate, amenorrhea (in females), weakness, cold intolerance, lethargy, and loss of libido and of axillary and pubic hair. There may be bradycardia or hypotension, and progression of the disorder leads to premature wrinkling of the skin and atrophy of the thyroid and adrenal glands. Treatment consists of the administration of the hormones of the target organs. Panhypopituitarism may also be caused by pituitary apoplexy, hemorrhage, or head trauma. Also called hypophyseal cachexia, pituitary cachexia, Simmonds' disease.

Sheehan syndrome

A condition that follows postpartum uterine haemorrhage severe enough to cause circulatory collapse, resulting in pituitary necrosis and hypopituitarism, especially if disseminated intravascular coagulation (DIC) was also present.

Clinical findings
Galactorrhoea, amenorrhoea or oligomenorrhoea, secondary hypothyroidism, cold intolerance, hypotension, bradycardia, weight gain, hair loss, adrenal insufficiency, fatigue, loss of libido, hypoglycaemia, hyponatraemia.

panhypopituitarism

Pituitary dwarfism, see there.

pan·hy·po·pi·tu·i·tar·ism

(PHP) (pan-hī'pō-pi-tū'i-tă-rizm)
A state in which the secretion of all anterior pituitary hormones is inadequate or absent.
Synonym(s): hypophysial cachexia.

Panhypopituitarism

Generalized decrease of all of the anterior pituitary hormones.
Mentioned in: Pituitary Dwarfism

panhypopituitarism

reduced or inadequate secretion of anterior pituitary hormones, due to pituitary destruction (e.g. secondary to local benign tumour)

pan·hy·po·pi·tu·i·tar·ism

(pan-hī'pō-pi-tū'i-tă-rizm) [MIM*312000]
A state in which secretion of all anterior pituitary hormones is diminished.
Synonym(s): hypophysial cachexia.

panhypopituitarism (panhī´pōpi-too´itəriz´əm),

n a deficiency involving all the hormonal functions of the pituitary gland. See also disease, Simmonds'.

panhypopituitarism

generalized hypopituitarism due to absence or damage to the pituitary gland, which in its complete form, leads to absence of gonadal function and insufficiency of thyroid and adrenal function. When cachexia is a prominent feature, it is called simmonds' disease or pituitary cachexia.

juvenile panhypopituitarism
most frequent in German shepherd dogs but also in other breeds; puppy dwarfism not apparent until 2-3 months old; small stature, delayed dentition, alopecia, infantile genitalia and short life span are characteristic. See also German shepherd dog dwarfism.