A study of new ventilation strategies guided by transpulmonary pressure in ECMO to determine the optimal PEEP to limit atelectrauma
is ongoing in our center (ClinicalTrials.
T] accurately to avoid underventilation or overdistension, deliver accurate pressures to avoid barotrauma, and has the ability to optimise PEEP to avoid atelectrauma
and maintain the set Fi[O.
VILI is a complex collection of lung deconstuctive elements that manifests itself in a number of forms including but is not limited to the following categories of ventilator induced lung injury; Volutrama, Barotrauma, Biotrauma, RACE and Atelectrauma
The deleterious effects from loss of positive end expiratory pressure (PEEP) on lung function and mechanics that occurs when patients are disconnected from the ventilator include a reduction in functional residual capacity, possible atelectrauma
and a decrease in oxygenation (Amato et al 1998, Barker and Adams 2002, McCann et al 2001, Savian et al 2005).
If intra-airway propagation is a genuine hazard, timing of PEEP application and positioning may be of under-recognized importance for reasons unrelated to atelectrauma
HFV helps to reduce barotrauma with low pressures, biotrauma and atelectrauma