as a therapeutic target for neurodegenerative diseases.
This suggests that damage may have involved astrogliosis
while the astrocyte cell membrane remained intact, and that persistent or secondary injury may be responsible for ongoing NFL elevation.
For example, Rrapo and colleagues (2009) used green tea, a powerful polyphenol, to reduce astrogliosis
in HIV-1 Tat transgenic mice.
burgdorferi may induce astrocytes to undergo astrogliosis
(proliferation followed by apoptosis), which may contribute to neurodysfunction.
29) In avian cases, histopathologic findings supportive of a diagnosis of hydrocephalus include atrophic periventricular and submeningeal tissues, with marked astrogliosis
secondary to ventriculomegaly and expansion of the subarachnoid space.
3) This results in blood flow away from the parenchyma, resulting in hypoperfusion, with consequent astrogliosis
, drusen-like debris and cholesterol accumulations in retinas from cholesterol-fed rabbits were observed.
post-hypoxia-ischemia (Oorschot and Galvin, 1995) would contribute to the smaller reduction in hemisphere weight.
Also, do we want to protect the neurons, the oligodendrocytes, the glia; do we want to stop the astrogliosis
, maintain a normal metabolism, enhance (endogenous) restorative mechanisms, supply trophic support; or some mixture of all of these goals?
Examination of a frontal cortex biopsy found diffuse astrogliosis
and microgliosis of gray and white matter, perivascular and parenchymal CD3+ T-cell infiltrates, neuronal loss, and axonal swelling.
The higher expression of GFAP in the cortex surrounding the lesion side reflects enhanced astrogliosis
Interestingly, SCID mice inoculated with macrophages and microglia with HIV-1 showed prominent neuropathological damages including astrogliosis