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astemizole |
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astemizole (  stem´izōl),n brand name: Hismanal; drug class: antihistamine, H1-histamine antagonist; action: decreases allergic response by blocking pharmacologic effects of histamine; uses: rhinitis, allergy symptoms. astemizole a long-acting, non-sedating H1-blocking antihistamine used in the treatment of pruritus in dogs and cats. |
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Astemizole reduced the number of parasites by 80 percent in mice infected with a strain sensitive to chloroquine, one of the primary antimalaria drugs, and by 44 percent in mice with chloroquine-resistant parasites, the researchers report in the August Nature Chemical Biology. Patients were given 5, 10, or 20 mg/day of astemizole for 13 weeks. More than 100 million prescriptions were written for terfenadine and astemizole before they were withdrawn from the market because of torsades and sudden death. |
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astemizole
