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aspartate aminotransferase |
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aspartate aminotransferase an enzyme that catalyzes the reversible transfer of an amino group: $$\eqalign{\hbox{aspartic acid + \alpha-ketoglutaric acid }\cr \hbox{\quad\leftrightharpoonsarrow\,\! oxaloacetic acid + glutamic acid}}$$ requiring the coenzyme pyridoxal phosphate; abbreviated AST. It is present in many tissues and body fluids. The serum concentration is elevated when damage to tissue cells, especially of the heart and liver, causes a release of the enzyme. AST values are also increased in some muscle diseases, such as enzootic muscular dystrophy. The test has limitations because of its lack of organ specificity. Called also (serum) glutamic-oxaloacetic aminotransferase (GOT or SGOT). |
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By day 4 of hospitalization, the patient's level of creatine phosphokinase had elevated to 146 266 U/L, the level of aspartate aminotransferase was 3082 U/L, the level of alanine aminotransferase was 1144 U/L, and the level of lactate dehydrogenase was 4687 U/L. The liver enzyme aspartate aminotransferase, an indicator of fatty liver disease, was detected in the blood samples of 42% of obese males tested and just 3% of males of 'normal weight'. Liver function was assessed in serum by measuring alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities (Bergmeyer and Horder 1980). |
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