aspartate aminotransferase

aspartate aminotransferase

n. Abbr. AST

See SGOT.

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aspartate aminotransferase (AST)

[aspär′tāt]

an enzyme normally present in body serum and in certain body tissues, especially those of the heart and liver. This enzyme affects the intermolecular transfer of an amino group from aspartic acid to alpha-ketoglutaric acid, forming glutamic acid and oxaloacetic acid. The reaction is reversible. The enzyme is released into the serum because of tissue injury and thus may increase as a result of myocardial infarction and liver damage. Normal findings for adults are 8 to 20 U/L or 5 to 40 IU/L. Previously called glutamic-oxaloacetic transaminase, serum glutamic oxaloacetic transaminase. Compare alanine aminotransferase.

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aspartate aminotransferase

an enzyme that catalyzes the reversible transfer of an amino group:

$$\eqalign{\hbox{aspartic acid + \alpha-ketoglutaric acid }\cr \hbox{\quad\leftrightharpoonsarrow\,\! oxaloacetic acid + glutamic acid}}$$

requiring the coenzyme pyridoxal phosphate; abbreviated AST. It is present in many tissues and body fluids. The serum concentration is elevated when damage to tissue cells, especially of the heart and liver, causes a release of the enzyme. AST values are also increased in some muscle diseases, such as enzootic muscular dystrophy. The test has limitations because of its lack of organ specificity. Called also (serum) glutamic-oxaloacetic aminotransferase (GOT or SGOT).

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aspartate aminotransferase

GOT, glutamate oxaloacetate transaminase AST A cytoplasmic and mitochondrial transaminase enzyme that catalyzes the reaction of aspartate and 2-oxoglutarate yielding glutamate and oxaloacetate; the transport of amino acids is central to protein buildup-anabolism or breakdown-catabolism; AST is ↑ in hepatic, myocardial, renal and cerebral infarction, and in hepatic and skeletal muscle disease

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Patient discussion about aspartate aminotransferase.

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Q. I think I have got involved with a man who had a bipolar, he never mentioned it I need to talk to somebody,pls The problem is he would never even admit it if I ever ask him. He's nice and caring and the next day he would disapearing without any reason, after a few weeks he would come back again even without saying sorry and repeats over and over again.... I need to talk to somebody... Thank you

A. Have you thought of writing to him about how you feel? I find sometimes writing out my feelings helps me and also ensures you get out all that you want to say without interuption. When you are in his presance how does he behave? Any sign of bipolar syptoms? Is he easily agitated, lots of energy or problems sleeping or any signs of depression?
Also does he have people living close to him? Any children, friends etc that you may be able to talk to about your concerns? They may be able to shed some light on this situation for you.