aspartate aminotransferase


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Related to aspartate aminotransferase: alkaline phosphatase, Aspartate Aminotransferase Test, alanine aminotransferase, Gamma glutamyl transferase

as·par·tate a·mi·no·trans·fer·ase (AST),

an enzyme catalyzing the reversible transfer of an amine group from l-glutamate to oxaloacetate, forming α-ketoglutarate and l-aspartate; an aid in diagnosing viral hepatitis and myocardial infarction.

aspartate aminotransferase (AST)

[aspär′tāt]
an enzyme normally present in body serum and in certain body tissues, especially those of the heart and liver. This enzyme affects the intermolecular transfer of an amino group from aspartic acid to alpha-ketoglutaric acid, forming glutamic acid and oxaloacetic acid. The reaction is reversible. The enzyme is released into the serum because of tissue injury and thus may increase as a result of myocardial infarction and liver damage. Normal findings for adults are 8 to 20 U/L or 5 to 40 IU/L. Previously called glutamic-oxaloacetic transaminase, serum glutamic oxaloacetic transaminase (SGOT). Compare alanine aminotransferase.

aspartate aminotransferase

GOT, glutamate oxaloacetate transaminase AST A cytoplasmic and mitochondrial transaminase enzyme that catalyzes the reaction of aspartate and 2-oxoglutarate yielding glutamate and oxaloacetate; the transport of amino acids is central to protein buildup-anabolism or breakdown-catabolism; AST is ↑ in hepatic, myocardial, renal and cerebral infarction, and in hepatic and skeletal muscle disease

as·par·tate a·mi·no·trans·fer·ase

(AST) (as-pahr'tāt ă-mē'nō-trans'fĕr-ās)
An enzyme catalyzing the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming α-ketoglutaric acid and l-aspartic acid; a diagnostic aid in viral hepatitis and in myocardial infarction.
Synonym(s): glutamic-oxaloacetic transaminase, serum glutamic-oxaloacetic transaminase.

aspartate aminotransferase

One of the enzymes released into the blood when tissue, such as liver or heart muscle, is damaged. Measurement of the level of such enzymes gives a useful indication of the extent of the damage.

aspartate aminotransferase

an enzyme that catalyzes the reversible transfer of an amino group:
$$\eqalign{\hbox{aspartic acid + \alpha-ketoglutaric acid }\cr \hbox{\quad\leftrightharpoonsarrow\,\! oxaloacetic acid + glutamic acid}}$$
requiring the coenzyme pyridoxal phosphate; abbreviated AST. It is present in many tissues and body fluids. The serum concentration is elevated when damage to tissue cells, especially of the heart and liver, causes a release of the enzyme. AST values are also increased in some muscle diseases, such as enzootic muscular dystrophy. The test has limitations because of its lack of organ specificity. Called also (serum) glutamic-oxaloacetic aminotransferase (GOT or SGOT).

Patient discussion about aspartate aminotransferase

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References in periodicals archive ?
Separate enzymatic microassays for aspartate aminotransferase isoenzymes.
Serum activities of sorbitol dehydrogenase, aspartate aminotransferase, and beta-glucuronidase were assessed using kits form Sigma Chemical Co (St Louis, MO) according to the manufacturer's instructions.
Serum test results included the following: aspartate aminotransferase, 4007 U/L (reference interval, 11-47 U/L); alanine aminotransferase, 715 U/L (reference interval, 7-53 U/L); alkaline phosphatase, 67 U/L (reference interval, 38-126 U/L); lactate dehydrogenase, 6150 U/L (reference interval, 100-250 U/L); creatinine, 1.
Biochemical indicators, such as cytotoxicity, TG level, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and intracellular reactive oxygen species, were used to evaluate the analogous pathological stage of NAFLD.
In addition, the liver enzymes alanine transaminase (ALT) and aspartate aminotransferase (AST) were elevated in the MK-0893/metformin group, and total cholesterol and LDL cholesterol were increased from baseline with MK-0893 /sitagliptin, relative to reductions with MK-0893 / metformin and sitagliptin/metformin, he reported.
The concentration of plasma urea nitrogen, alanine aminotransferase, aspartate aminotransferase, total cholesterol, low-density lipoprotein, high-density lipoprotein and creatinine was measured with an Automatic Biochemical Analyzer (RA-1000; Bayer Corporation, Tarrytown, NY) using colorimetric methods and the instructions from the manufacturer's reagent kit (Zhongsheng Biochemical Company, Beijing, China).
Serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels were 12 U/L, 5 U/L, and 425 U/L, respectively.
WESR was 30 mm/h, aspartate aminotransferase 127 MU/mL, alanine aminotransferase 192 MU/mL, total bilirubin 0.
Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (AP) were measured using kits from Sigma, according to the manufacturer's instructions.
Alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, creatinine, alkaline phosphatase and total proteins were determined using commercial kits (Laborlab, Guarulhos, Brazil).
At this time, the aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels became elevated (Table 1).
Among the 15 patients who completed the study, reductions in alanine aminotransferase (ALT) were observed in 11 patients and aspartate aminotransferase (AST) in 10 patients.