Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl
hydroxylation of ankyrin repeat domain-containing proteins.
Stability of adrenocorticotropic hormone (ACTH) and pathways of deamidation of asparaginyl
residue in hexapeptide segments.
The hydroxylation is catalyzed by a variety of nonheme iron-containing dioxygenases, including prolyl, asparaginyl, and lysyl hydroxylases (Hewitson et al.
Among them are two long-known collagen prolyl-4-hydroxylases (Myllyharju 2003), the more recently identified FIH-1 (factor inhibiting HIF), and PHD1-3, asparaginyl and prolyl hydroxylases, responsible for HIF-[alpha] protein hydroxylation (Epstein et al.
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.
The stability and degradation pathway of recombinant human parathyroid hormone: deamidation of asparaginyl
residue and peptide bond cleavage at aspartyl and asparaginyl
Objective: This project entitled Synthesis of Truncated tirandamycin A-D derivatives as new Antihelminthic Agents (STTDAA) aims at developing novel asparaginyl
tRNA synthetase (AsnRS) inhibitors as potential antihelminthic agents, with new mechanisms of action for potential treatment of lymphatic filariasis (LF).
9-Da marker peptide appeared in the Hb variant [[beta]66 Lys[right arrow]Asn] only, but not in wild-type Hb, and was confirmed to be an amino acid substitution by elimination of the tryptic cleavage site at Lys([beta]66) and by the characteristic mass increase of 114 Da, which indicated the addition of an asparaginyl
residue to this position.
Structure of the EF corner favors deamidation of asparaginyl residues in hemoglobin: the example of Hb La Roche-sur-Yon [[beta]81(EF5)Leu [right arrow] His].
Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.
Evolution and the distribution of glutamyl and asparaginyl residues in proteins.