Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor
This study evaluated the usefulness of asialoglycoprotein receptor
scintigraphy with [sup.
03 mg/kg of recombinant ApoE was able to fully restore the activity of an siRNA formulated in an iLNP; and,aA alternatively, in the same ApoE knockout model, silencing activity was found to be restored by the use of an exogenous GalNAc ligand that targets the iLNP to the asialoglycoprotein receptor
(ASGR) expressed on hepatocytes, with as little as 0.
Using the hepatocyte-specific asialoglycoprotein receptor
and the substance that specifically binds to it (i.
A 3D model for the human hepatic asialoglycoprotein receptor
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor
, is an entry point for Marburg virus.
GalNAc-siRNA conjugates are a proprietary Alnylam delivery platform and are designed to achieve targeted delivery of RNAi therapeutics to hepatocytes through uptake by the asialoglycoprotein receptor
For example, competition for clearance by the asialoglycoprotein receptor
of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).
GalNAc-conjugate siRNA are designed to achieve targeted delivery of RNAi therapeutics to hepatocyte cells of the liver through uptake by the asialoglycoprotein receptor
Our patient had tested negative for acute and chronic viral hepatitis as well as asialoglycoprotein receptor
Further, iLNPs were engineered with the carbohydrate N-acetylgalactosamine (GalNAc) to achieve targeting to the asialoglycoprotein receptor
(ASGPR) as an alternative targeting strategy for the hepatic delivery of RNAi therapeutics.
Senior Vice President of Science and Medical Affairs said, "This manuscript provides a detailed correlation between the size and shape of compacted DNA complexes and successful targeting of liver cells expressing the asialoglycoprotein receptor