This study evaluated the usefulness of asialoglycoprotein receptor
scintigraphy with [sup.
A 3D model for the human hepatic asialoglycoprotein receptor
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor
, is an entry point for Marburg virus.
GalNAc-siRNA conjugates are a proprietary Alnylam delivery platform and are designed to achieve targeted delivery of RNAi therapeutics to hepatocytes through uptake by the asialoglycoprotein receptor
For example, competition for clearance by the asialoglycoprotein receptor
of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).
GalNAc-conjugate siRNA are designed to achieve targeted delivery of RNAi therapeutics to hepatocyte cells of the liver through uptake by the asialoglycoprotein receptor
Our patient had tested negative for acute and chronic viral hepatitis as well as asialoglycoprotein receptor
The technology is designed to enable direct intravenous injection of "gene drugs" targeted specifically to the asialoglycoprotein receptor
on liver cells.
Further, iLNPs were engineered with the carbohydrate N-acetylgalactosamine (GalNAc) to achieve targeting to the asialoglycoprotein receptor
(ASGPR) as an alternative targeting strategy for the hepatic delivery of RNAi therapeutics.
The receptor, called the asialoglycoprotein receptor
, facilitates entry of the complex into the cell.
Senior Vice President of Science and Medical Affairs said, "This manuscript provides a detailed correlation between the size and shape of compacted DNA complexes and successful targeting of liver cells expressing the asialoglycoprotein receptor
Autoantibodies to asialoglycoprotein receptor
, which is expressed on the surface of hepatocytes, were found in 50-80% of patients with AIH (24, 25).