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A glycoprotein without a sialic acid moiety; such proteins are recognized by asialoglycoprotein receptors and are targeted for degradation.
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Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor.
Autoantibodies detected in CLDs target a wide repertoire of host antigens, which include proteins from the nucleus, the cytoskeleton, liver kidney microsomes, the mitochondria, and the cytoplasm of neutrophilic granulocytes, as well as liver soluble antigens, asialoglycoprotein receptors, TAA, and stress proteins [21].
Both Ebola and Marburg viruses use multiple entry mechanisms via receptors such as: hepatocyte receptor asialoglycoprotein, folate receptor [alpha], dendritic-cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), DC-SIGN-related factors, [beta]1 integrin receptors and human macrophage galactose- and N-acetylgalactosamine-specific C type lectin.
Topology of asialoglycoprotein receptor in rat liver subcellular fractions: a ferritin immunoelectron microscopic study.
03 mg/kg of recombinant ApoE was able to fully restore the activity of an siRNA formulated in an iLNP; and,aA alternatively, in the same ApoE knockout model, silencing activity was found to be restored by the use of an exogenous GalNAc ligand that targets the iLNP to the asialoglycoprotein receptor (ASGR) expressed on hepatocytes, with as little as 0.
The galactose group is recognizable to the hepatic asialoglycoprotein receptors.
Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirrhosis.
On the sinusoidal surface of the hepatocytes, asialoglycoprotein receptors are expressed abundantly which removes the asialo (galactose-terminal) glycoproteins from the sinusoidal circulation by internalizing the bound protein via endocytosis.
Using the hepatocyte-specific asialoglycoprotein receptor and the substance that specifically binds to it (i.
12] analogs and transporting them to the liver via an asialoglycoprotein receptor for secretion into bile.
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor, is an entry point for Marburg virus.

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