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A glycoprotein without a sialic acid moiety; such proteins are recognized by asialoglycoprotein receptors and are targeted for degradation.
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RG-101 is a novel anti-miR-122 oligonucleotide therapeutic that is effectively targeted to hepatocytes for the treatment of HCV through conjugation to GalNAc, a carbohydrate-based chemistry approach for asialoglycoprotein receptor-mediated delivery of oligonucleotides to hepatocyte cells of the liver.
Topology of asialoglycoprotein receptor in rat liver subcellular fractions: a ferritin immunoelectron microscopic study.
Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirrhosis.
On the sinusoidal surface of the hepatocytes, asialoglycoprotein receptors are expressed abundantly which removes the asialo (galactose-terminal) glycoproteins from the sinusoidal circulation by internalizing the bound protein via endocytosis.
Using the hepatocyte-specific asialoglycoprotein receptor and the substance that specifically binds to it (i.
12] analogs and transporting them to the liver via an asialoglycoprotein receptor for secretion into bile.
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor, is an entry point for Marburg virus.
GalNAc-siRNA conjugates are a proprietary Alnylam delivery platform and are designed to achieve targeted delivery of RNAi therapeutics to hepatocytes through uptake by the asialoglycoprotein receptor.
GalNAc-siRNAs are designed to achieve targeted delivery of RNAi therapeutics to hepatocyte cells of the liver through uptake by the asialoglycoprotein receptor.
For example, competition for clearance by the asialoglycoprotein receptor of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).

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