ascending dose study

ascending dose study

A component of a phase-I clinical trial in which increasing doses of a drug are administered until the maximum tolerated dose is reached.
References in periodicals archive ?
CNS") in Long Beach, California, for the ongoing 28-day, first-in-human randomized, double-blind, controlled, ascending dose study of orally dosed RT001 to evaluate the safety, tolerability, pharmacokinetics (PK), disease state, and exploratory endpoints in patients with Friedreich's ataxia (FA).
The Company also announces the commencement of a multiple ascending dose study in up to 30 moderate chronic obstructive pulmonary disease (COPD) patients, where each dose will be given for five consecutive days.
COPENHAGEN, Denmark, April 28, 2015 /PRNewswire/ -- Ascendis Pharma A/S (Nasdaq: ASND), a clinical stage biotechnology company that applies its TransCon technology to address significant unmet medical needs, announced today that its Phase 1 single ascending dose study of TransCon Treprostinil produced dose-dependent increases in plasma treprostinil levels in-line with expectations.
A lead H4 antagonist has completed a Phase 1 multiple ascending dose study.
The two E2609 Phase I studies presented at the AAIC 2012 comprised a single oral ascending dose study (Study A001-001) which showed Abeta levels reduction in plasma, and a 14-day multiple oral ascending dose study (Study A001-002) which showed dose-dependent increase of E2609 PK level and statistically significant reduction of Abeta levels in cerebrospinal fluid (CSF).
Data from this single and multiple ascending dose study demonstrated that CH-4051 is safe and well tolerated up to a maximally tolerated dose of 7.
Eight patients, five men and three women aged 25-40 years, were recruited for a placebo-controlled, balanced, ascending dose study, in which all patients received one oral dose of 0.
This Phase 1 study was a multi-part, randomized, single-blind, placebo-controlled, single ascending dose study to evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of TRV130 in healthy adult males.
In addition, Hapten Sciences is planning a multiple ascending dose study in individuals that are sensitive to poison ivy.
Single ascending dose study in 50 healthy volunteers up to a dose
14, 2015 /PRNewswire/ -- Ascendis Pharma A/S, a clinical stage biotechnology company that applies its innovative TransCon technology to address significant unmet medical needs, today announced that it has initiated a Phase 1 single ascending dose study of TransCon Treprostinil in healthy volunteers.
16, 2015 /PRNewswire/ -- Turing Pharmaceuticals AG, a privately-held biopharmaceutical company focused on developing and commercializing innovative treatments for serious diseases and conditions, today announced dosing of the first group of subjects in the TUR-004 single ascending dose study, the first clinical study in a comprehensive program aimed at obtaining approval for the treatment of epileptic encephalopathies.