ascending dose

ascending dose

The administration of increasing doses of a drug until a desired effect is achieved.
References in periodicals archive ?
APD371 was evaluated in Phase 1 studies to assess the safety, tolerability and pharmacokinetics of a single ascending dose or multiple ascending doses in healthy volunteers.
Asias premier biopharmaceuticals company, and JDRF, the leading global organization funding type 1 diabetes (T1D) research and advocacy worldwide, jointly announced a JDRF partnership to support a global multiple ascending dose study with a novel oral insulin drug candidate, Insulin Tregopil, in people with T1D.
Pharmaceutical company PharmAkea Inc reported on Monday the completion of its Phase 1 single and multiple ascending dose (SAD/MAD) clinical study of PAT-1251.
Clinical development of MK-8719 was initiated with a single ascending dose Phase I study in healthy adult subjects to evaluate the safety, tolerability, and plasma pharmacokinetics of MK-8719.
The two E2609 Phase I studies presented at the AAIC 2012 comprised a single oral ascending dose study (Study A001-001) which showed Abeta levels reduction in plasma, and a 14-day multiple oral ascending dose study (Study A001-002) which showed dose-dependent increase of E2609 PK level and statistically significant reduction of Abeta levels in cerebrospinal fluid (CSF).
Both single ascending dose and multiple ascending dose Phase I studies of ICA-105665 have been completed.
The Phase I trial of V24343, a CB1 antagonist, will be a double-blind, randomized, placebo-controlled study in overweight and mildly obese volunteers and will be conducted in two parts: a single ascending dose followed by a multiple ascending dose.
The TAFA93 Phase Ia single center, randomized, placebo-controlled, Single Ascending Dose (SAD) trial began in July 2004.
The study comprised six ascending dose groups each given CDP-791 intravenously once every three weeks.
M2 PHARMA-November 21, 2017-Promentis Pharmaceuticals Begins Ascending Dose Study of SXC-2023 for Treatment of Neuropsychiatric Disorders
Data from this single and multiple ascending dose study demonstrated that CH-4051 is safe and well tolerated up to a maximally tolerated dose of 7.