artificial liver


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An extracorporeal supportive device for a person with acute liver failure. Bioartificial livers are not intended as permanent replacements, but as stop-gaps while one is awaiting liver transplantation. The current generation devices contain hepatocytes embedded in a gel. The patient’s plasma is removed and circulated through the device and returned, minus the metabolic wastes produced by the body which are normally removed by a healthy liver

artificial liver

Biotech A cartridge with cloned human liver cells, through which blood flows to facilitate removal of waste products. See Extracorporeal liver assist device, Liver dialysis.

artificial liver

A biomechanical device typically combining a system of filters to remove toxins from the blood with hepatic cells or tissue. It is designed to support patients with hepatic failure temporarily until a donor liver becomes available for transplantation.
See also: liver

artificial liver

An as yet unrealized entity that is, nevertheless, the subject of promising research and development. Current ambitions are to produce extracorporeal devices that will enable patients with liver failure to be kept alive until regeneration of transplantation is achieved. The principal difficulty arises from the large number of different metabolic functions performed by the liver. A promising approach is the use of cloned human liver cells grown around numerous fine semipermeable tubules through which the patient's blood is passed.
References in periodicals archive ?
These results suggest that HepaLife's bioartificial liver system is an artificially created, "living biosystem" -- our goal from the early beginning -- with cells that behave as we have long desired for our artificial liver device," concluded Menzler.
As we progress and surpass each of our research objectives for our proprietary cell line - which, to-date has performed beyond our expectations - we move closer and closer to making the development of an artificial liver device a reality for the millions of individuals who suffer from liver disease.
They also gave consent for the plan because the only effective treatment for acute liver failure is a liver transplant and there is high demand for artificial livers.
Al Naqbi explained that the artificial liver he invented consists of three chambers, while the industrial liver used medically consists of only two.
Those tougher cells could make artificial liver devices more effective.
The present contract is the supply, installation and commissioning of apparatus for hemodialysis, water conditioner (individual for each camera to hemodialysis) renal replacement techniques, apparatus and apparatus for artificial liver assist with carrying out the training.
Researchers Colin McGucklin, professor of Regenerative Medicine at Newcastle University and Nico Forraz, senior research associate and Clinical Sciences Business Manager at Newcastle, report the pieces of artificial liver can be used to repair livers injured by disease, alcohol abuse, injury or other causes in the next five years.
That short-term support is what is offered by artificial liver devices.
Einstein Medical Center Participates in Artificial Liver
The company says the findings are crucial to successfully developing an artificial liver device.
The ability to survive in human plasma is especially significant since a functioning artificial liver device is expected to separate liver failure patients' plasma from whole blood, and subsequently process the plasma by way of the PICM-19H cells.
The major product segments analyzed are Artificial Heart, Artificial Kidneys, Artificial Liver, Artificial Pancreas, and Artificial Lungs.