artificial chromosome


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Related to artificial chromosome: Bacterial artificial chromosome

artificial chromosome

n.
A large sequence of DNA, such as a human artificial chromosome or a bacterial artificial chromosome, that is constructed in a laboratory to function like a chromosome or inserted into a cell to be replicated and expressed. Artificial chromosomes have been used in gene mapping and in modeling genetic diseases.

artificial chromosome

The result of a biotechnology still at an experimental stage. Human chromosomes, consisting of a centromere of highly repetitive DNA sequences, telomeric DNA, a marker gene and some random sequences of genomic DNA, have been successfully prepared. When these ingredients were introduced into a human cell line they became coated with histone proteins and formed highly coiled structures. They also replicated and passed on copies to daughter cells through more than 200 cell divisions.
References in periodicals archive ?
Integration-free iPS cells engineered using human artificial chromosome vectors.
She said that the point of creating the human artificial chromosome project is to develop a shuttle vector for gene delivery into human cells to study gene function in human cells.
Abbreviations: BAC, bacterial artificial chromosomes; BAC-FISH, fluo-rescently labeled bacterial artificial chromosome in situ hybridization; DAPI, 4'-6-diamidino-2-phenylindole; FISH, fluorescent in situ hybridization; FSW, filtered seawater; PABA.
Genome-wide copy number profiling on high-density bacterial artificial chromosomes, single-nucleotide polymorphisms, and oligonucleotide microarrays: a platform comparison based on statistical power analysis.
Further incorporation of the bovine bacterial artificial chromosome (BAC) clones into the RH map (Larkin et al.
A vast amount of genetics and breeding work has been done in this cereal crop since last century, Genetic linkage maps, physical maps, deletion lines maps and Bacterial Artificial Chromosome (BAC) libraries have also been developed (McIntosh 1987).
NIAS and STAFF will produce a draft sequence of the genome from the Bacterial Artificial Chromosome region commissioned by the Sanger Institute.
Anchoring 9371 maize expressed sequence tagged unigenes to the bacterial artificial chromosome contig map by two-dimensional overgo hybridization.
In 2002 Kirin made use of a proprietary human artificial chromosome vector to introduce human antibody genes into bovine cells and, using Hematech's technology, created cows capable of producing human antibody proteins and bovine antibody proteins.
Chromosome loss is very common in chromosome preparation, so there were only 71% diploids in normal diploid group in this study, others being represented as aneuploids after artificial chromosome loss.
The newer techniques, like FISH and CGH to bacterial artificial chromosome (BAC) clones, can identify abnormalities as small as 0.
And in June 2001, Monsanto shared a series of bacterial artificial chromosome (BAC)-end sequences with BBI.

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