These include presentation of an arthritogenic
peptide of Yersinia and Chlamydia by particular HLA-B27 alleles8, aberrant/ misfolded expression of HLA-B27 heavy chains and enhanced intracellular microbial survival9.
Persistent chronic inflammation and infection by Chikungunya arthritogenic
alphavirus in spite of a robust host immune response.
alphaviruses: new insights into arthritis and bone pathology.
Invasion of endothelial cells and arthritogenic
potential of endocarditis-associated Corynebacterium diphtheria.
Adjuvant oil induces waves of arthritogenic
lymph node cells prior to arthritis onset.
The higher percentage of mature DCs in the positive control group shows that the arthritogenic
process is associated with an increased maturation of DCs.
They address genome structure and replication, laboratory diagnosis and detection, interaction with the interferon system, antiviral responses in mosquitoes, animal models of alphavirus-induced inflammatory disease, clinical manifestations of arthritogenic
alphaviruses, encephalitic alphaviruses, the application of alphaviruses for gene therapy, and chikungunya virus pathogenesis and the development of control strategies.
Pristane, a non-antigenic adjuvant, induces MHC classII- Restricted, arthritogenic
T cells in the Rat.
Louis, describe a cohort of 10 Americans who traveled to Haiti within a 20-day period in June 2014 and became infected with Chikungunya virus (CHIKV), an arthritogenic
, mosquito-transmitted alphavirus (Arthritis Rheumatol.
Different hypotheses exist, such as the arthritogenic
peptide hypothesis, the misfolding hypothesis or molecular mimicry (3-5).
This occurs when HLA-B27 presents arthritogenic
microbial peptides to T-cells, thereby stimulating an auto-immune response.
Relationship between Thl/TTh2 cytokine patterns and the arthritogenic
response in collagen-induced arthritis.