Twenty years later, the arthritogenic
pathogenesis of viruses in the ECSA chikungunya virus lineage was confirmed after outbreaks in the Indian Ocean region (2-5,7,8).
Louis, describe a cohort of 10 Americans who traveled to Haiti within a 20-day period in June 2014 and became infected with Chikungunya virus (CHIKV), an arthritogenic
, mosquito-transmitted alphavirus (Arthritis Rheumatol.
Different hypotheses exist, such as the arthritogenic
peptide hypothesis, the misfolding hypothesis or molecular mimicry (3-5).
This occurs when HLA-B27 presents arthritogenic
microbial peptides to T-cells, thereby stimulating an auto-immune response.
Chaperonin Protein 14-3-3n (eta) in Rheumatoid Arthritis and Arthritogenic
Viral Infections Presenter: S.
Relationship between Thl/TTh2 cytokine patterns and the arthritogenic
response in collagen-induced arthritis.
Type XI collagen is arthritogenic
in rats but not mice; type IX induces autoimmunity in both species but not arthritis.
Although the exact etiology is uncertain, RA is multifactorial and currently believed to be triggered by exposure of an immunogenetically susceptible host to an arthritogenic
parvovirus B19 transgenic mice are highly susceptible to polyarthritis (5), and the double stranded viral RNA has overt arthritogenic
Investigations are also under way to attempt to induce tolerance to supposed arthritogenic
antigens by monoclonal antibodies, other biologic agents, and vaccination or oral administration of antigen.
Inflammatory lipoproteins purified from a toxigenic and arthritogenic
strain of Mycoplasma arthritidis are dependent on Toll-like receptor 2 and CD14.
monoclonal antibodies from K/BxN mice.