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arteriosclerosis obliterans

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia 0.01 sec.
arteriosclerosis /ar·te·rio·scle·ro·sis/ (-sklĕ-ro´sis) a group of diseases characterized by thickening and loss of elasticity of the arterial walls, occurring in three forms: atherosclerosis, Mönckeberg's arteriosclerosis, and arteriolosclerosis.arteriosclerot´ic
Mönckeberg's arteriosclerosis  arteriosclerosis with extensive deposits of calcium in the middle coat of the artery.
arteriosclerosis obli´terans  that in which proliferation of the intima of the small vessels has caused complete obliteration of the lumen of the artery.
peripheral arteriosclerosis  arteriosclerosis of the limbs.

arteriosclerosis o·blit·er·ans (-blt-rnz)
n.
Arteriosclerosis producing narrowing and occlusion of the arterial lumen.

arteriosclerosis obliterans
Etymology: Gk, arteria + skleros + L, obliterare, efface
a gradual narrowing of the arteries with thrombosis and degeneration of the intima. The condition may lead to complete occlusion of an artery and subsequent gangrene.

arteriosclerosis [ahr-te″re-o-sklĕ-ro´sis]
any of a group of diseases characterized by thickening and loss of elasticity of the arterial walls; popularly called “hardening of the arteries.” Symptoms depend on the organ system involved. adj., adj arteriosclerot´ic.ƒ

There are three main forms of arteriosclerosis: (1) atherosclerosis, the most common type, in which plaques of fatty deposits form in the inner layer (tunica intima) of the arteries; (2) Mönckeberg's arteriosclerosis, called also medial calcific sclerosis because of involvement of the middle layer (tunica media) of the arteries, where there is destruction of muscle and elastic fibers and formation of calcium deposits; and (3) arteriolar sclerosis or arteriolosclerosis, which is marked by thickening of the walls of arterioles. All three forms may be present in the same patient, but in different blood vessels. When reference is made to hardening of the arteries, this usually refers to atherosclerosis; the terms arteriosclerosis and atherosclerosis are often used interchangeably.

It is the responsibility of the health care provider to help individuals modify or eliminate from their lives risk factors for the development of arteriosclerosis. These include cigarette smoking, obesity, elevated cholesterol levels, and sedentary life style.
Mönckeberg's arteriosclerosis see arteriosclerosis.
arteriosclerosis obli´terans arteriosclerosis in which proliferation of the intima has caused complete obliteration of the lumen of the artery. Cf. endarteritis obliterans.


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In Japan, the two companies are currently conducting phase II clinical studies of NM-702 for the treatment of intermittent claudication caused by arteriosclerosis obliterans and lumber spinal canal stenosis as well as bronchial asthma.
The team has confirmed that 80 percent of patients with severe cases of arteriosclerosis obliterans who would otherwise have had to have their legs amputated were spared such operations.
 
 
 
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