Microscopically, histopathology did not reveal malignancy, but tissue necrosis, widespread luminal compression secondary to vascular calcification, hyperplasia of the tunica intima, and inflammatory cell infiltration--consistent with a diagnosis of calcific uremic arteriolopathy.
Calcific uremic arteriolopathy is not completely understood, with a multifactorial pathogenesis.
The presentation of calcific uremic arteriolopathy in the early stages is typically with dysesthesia, progressing to an erythematous, violaceous rash similar to livedo reticularis.
2001a), renal afferent arteriolopathy
(Mazzali et al.
Calcific uremic arteriolopathy
(CUA) is the preferred and more descriptive term for what was pre viously known as calciphylaxis.
Cutaneous necrosis from calcific uremic arteriolopathy
36) Both LN and MCP showed even stronger statistical associations with other placental hypoxic lesions than with maternal and fetal status and were particularly associated with decidual arteriolopathy, multinucleated giant cells in decidua basalis, and excessive amount of extravillous trophoblasts in the placental disc (Table 2), just as they are associated with increased amount of migratory trophoblasts in the membranes themselves.
In summary, up to now, the placental membrane was a site looked at mainly for features of acute inflammation (chorioamnionitis), meconium, hemosiderin, amnion nodosum, and decidual arteriolopathy.
Calcific uremic arteriolopathy, more commonly referred to as calciphylaxis, is a vasculopathy, which presents as calcification of arteries and soft tissues and resulting skin and fat necrosis.
Calciphylaxis: Calcific uremic arteriolopathy and the emerging role of sodium thiosulfate.