Amlodipine is a calcium channel blocker ("CCB") having a hypotensive action by blocking inward calcium ion channels mainly in vascular smooth-muscle cells, resulting in peripheral arteriolar
Total peripheral vascular resistance increase is caused by arteriolar
vasoconstriction and arteriosclerosis.
Hyperventilation reduces the partial pressure of carbon dioxide, which causes cerebral arteriolar
constriction and, therefore, decreased cerebral blood volume, and so ICP.
diameter in DOCA-salt and two-kidney one-clip hypertensive rats.
The most common presenting manifestation is thrombosis, such as mural thrombus of the heart, inferior vena cava thrombosis, superficial venous thrombosis, portal thrombosis, deep venous thrombosis, cerebral arteriolar
and venous thrombosis, and intracardiac thrombi (2), (3), (4), (5) Simultaneous multiple organ thromboses associated with HES rare.
Perclot is a hemostat composed of absorbable polysaccharide granules and is intended for use in surgical procedures as an adjunctive hemostatic device when control of capillary, venular, and arteriolar
bleeding by pressure, ligature, and other conventional means is ineffective or impractical.
If endothelial-dependent vasodilatation is compromised, arteriolar
vasoconstriction with peripheral resistance occurs.
vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors.
Hyalinosis, where present, involved arteriolar
intima and was separately described.
A condition, such as MS, that leads to endothelial dysfunction is likely to have a manifestation in the ocular fundus, such as generalized retinal arteriolar
narrowing, arteriovenous nicking and retinal hemorrhages, microaneurysms and cotton wool spots.
During normal pregnancy, plasma volume expands as a result of arteriolar
vasodilatation, and arterial blood pressure falls (Duvekot et al.
In relation to the cardiovascular system, morphine has little effect on blood pressure or heart rate in the doses normally used for analgesia and anaesthesia, but at higher doses histamine released by morphine may sometimes play a role in arteriolar
and venous dilatation, decreased peripheral resistance and, in some situations, hypotension (51).