exerts exquisite anticancer activity in vitro (Efferth et al.
To demonstrate that parasite survival against exposure to artemisinin
resulted from quiescence involving a proliferation blockade (11), sorbitol treatment was performed immediately after a 24-h exposure of synchronized ring-stage cultures to 11 [micro]mol/L artemisinin
in the ring-stage growth arrest assay (11).
Malaria was easy to cure with early diagnosis and the help of Artemisinin
, Zhang said, adding the high mortality rates occurred in Angola mostly among pregnant women or children under the age of five from impoverished families in remote areas of the country.
According to the researchers, magnetic nanoliposomes containing artemisinin
and transferrin were produced in this research through extrusion method, and some of their physical and chemical properties were studied.
In the 1970's, artemisinin
was identified and extracted as an important constituent from the plant Artemisa annua, and demonstrated potent antimalarial activity despite poor pharmacokinetic activity.
Burma is considered the front line in the battle against artemisinin
resistance as it forms a gateway for resistance to spread to the rest of the world," said Woodrow, who led the Oxford study.
resistance has not yet been detected in Africa, but is a growing problem in southeast Asian nations like Cambodia, Thailand and Vietnam, and is suspected, though not proven, to have taken hold in South America.
She is currently seeking, with a major award from the National Institutes of Health, to learn more about other compounds that might serve as adjuncts to artemisinin
and its derivatives are most effective antimalarial drugs which act upon by selectively inhibiting Plasmodium falciparum ATPase6 protein, the only SERCA-type [Ca.
A report in the July 31 New England Journal of Medicine establishes that the scourge has found a way to skirt the effects of artemisinin
and its chemical derivatives, the best available antimalarial drugs.
Washington, July 31 ( ANI ): It has been recently revealed that resistance to the main drug, artemisinin
, used to treat Plasmodium falciparum malaria has been spreading at an alarming stage in Southeast Asia.
1, 2) In an effort to stem the bleak situation, the Federal Ministry of Health (FMOH) in Nigeria changed the malaria treatment policy from chloroquine (CQ) and sulfadoxine/pyrimethamine (SP) to Artemisinin
combination therapy (ACT), (2) with preference for Artemether/lumefantrine (ALU) and Artesunate/Amodiaquine (AS+AQ) combinations.