This will open up a new platform for realising the structural basis of the elusive GPCR regulation by arrestins
Arrestins are expressed proteins that were first described, and are well-known as negative regulators of G protein-coupled receptor (GPCR) signaling (4).
Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3alpha2 signaling complex.
Regulation of lipopolysaccharideinduced inflammatory response and endotoxemia by beta arrestins.
Opposing effects of inositol hexakisphosphate on rod arrestin and arrestin2 self-association.
A special section is included in this year's edition on [Beta]-arrestins
with topics that include the role of [Beta]-arrestin
-mediated signaling in chemotaxis cellular process, their role in regulating signaling by receptor tyrosine kinases (RTKs), and the role of G protein- coupled receptor kinases and arrestins
Our broadened claims covering arrestins
and any active label are now beginning to issue worldwide.
The proteins are, G protein-coupled receptor kinase 2, arrestins
2 and 3, and dynamin.
Regulation of G protein-coupled receptor kinases and arrestins
during receptor desensitization.
For cellular immunodetection of [beta]-arrestin
, we used a mouse monoclonal antibody that recognizes both arrestin
isoforms (BD Bioscience, San Diego CA), and for [beta]-arrestin
Western blot detection, an antibody generously provided by R.