aromatase inhibitors


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to aromatase inhibitors: tamoxifen

ar·o·mat·ase in·hib·i·tors

drugs, such as aminoglutethimide, that inhibit aromatase, an enzyme in estrogen synthesis reactions.

aromatase inhibitors

a class of drugs that inhibit aromatase activity and thus block production of estrogens. They are used to treat breast cancer and endometriosis.

aromatase inhibitors

A group of anti-cancer drugs that act by preventing the enzymatic conversion of androgens to oestrogens. These drugs are used especially in post-menopausal women with breast cancers that are being encouraged by oestrogens but that fail to respond to drugs such as tamoxifen. The third-generation aromatase inhibitors, developed in the early 1990s, which include anastrozole (Arimidex), letrozole (Femara) and exemestane (Aromasin), are now challenging tamoxifen as the treatment of choice in post-menopausal women with oestrogen-receptor-positive breast cancers.
References in periodicals archive ?
Anastrozole was the first aromatase inhibitor to be approved by the US Food and Drug Administration (FDA) as an adjuvant hormonal therapy in early stage breast cancer in 2002.
Aromatase inhibitor induces complete sex in protogynous honeycomb grouper, Epinephelus merra.
The present investigation was designed to better understand the aromatase based sex determination in fish using two functional treatments of tamoxifen (11p-hydroxyandrostenedione) an estrogen receptor blocker and letrozole (Cyp19) which is a known aromatase inhibitor.
However, much will depend on the patient, her characteristics, her bone health, and whether or not she has any preexisting conditions that would suggest she might experience more side effects on an aromatase inhibitor than on tamoxifen or raloxifene," she concludes.
In the present study, masculinization of undifferentiated yellow catfish was induced by administration of the aromatase inhibitor (AI) letrozol (LZ).
And there can be real benefits of taking aromatase inhibitors.
Aromatase inhibitors are currently used to treat breast cancer.
Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.
Keywords: Aromatase inhibitors, CA Ovary, Granulosa cell tumour, Anastrozole, Oncology Royal Hospital.
Aromatase inhibitors block the enzyme aromatase, which is responsible for conversion of the adrenal derived precursor, androstenedione, to estrogen in tissues such as fat, muscle, and in the breast in postmenopausal women.
CHICAGO - The bone loss associated with aromatase inhibitors was significantly slowed with increasing supplements of vitamin D in a prospective cohort study of 156 postmenopausal women.
Aromatase inhibitors reduce the amount of estrogen in the body by blocking the enzyme aromatase, which turns androgen into estrogen.