aromatase inhibitors


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to aromatase inhibitors: tamoxifen

ar·o·mat·ase in·hib·i·tors

drugs, such as aminoglutethimide, that inhibit aromatase, an enzyme in estrogen synthesis reactions.

aromatase inhibitors

a class of drugs that inhibit aromatase activity and thus block production of estrogens. They are used to treat breast cancer and endometriosis.

aromatase inhibitors

A group of anti-cancer drugs that act by preventing the enzymatic conversion of androgens to oestrogens. These drugs are used especially in post-menopausal women with breast cancers that are being encouraged by oestrogens but that fail to respond to drugs such as tamoxifen. The third-generation aromatase inhibitors, developed in the early 1990s, which include anastrozole (Arimidex), letrozole (Femara) and exemestane (Aromasin), are now challenging tamoxifen as the treatment of choice in post-menopausal women with oestrogen-receptor-positive breast cancers.
References in periodicals archive ?
Louis have found a way to relieve the joint and muscle pain that often accompanies aromatase inhibitors, allowing women to continue taking these medications.
Sonia Servaja of Hospital del Mar in Barcelona, and colleagues, assessed the association between 25-hydroxy-vitamin D (25[OH]D) concentrations and bone loss at baseline, after 3 months of supplementation, and after 1 year, in patients receiving aromatase inhibitor therapy for early-stage breast cancer.
In a double-blind, randomised, Phase III study in women receiving aromatase inhibitor therapy (n=252), denosumab increased lumbar spine BMD at 12 and 24 months versus placebo (P<0.
The aromatase inhibitors anastrozole, exemestane and letrozole, within their licensed indications, are recommended as options for the adjuvant treatment of early oestrogen-receptor-positive invasive breast cancer in postmenopausal women.
Thousands of women have already beat breast cancer thanks to recent research on aromatase inhibitors," says Dr.
The introduction of aromatase inhibitors in the last 2 years has contributed to the risk of osteoporosis in breast cancer patients, Dr.
The National Institute of Clinical Excellence (Nice)is looking at the use of aromatase inhibitors in the treatment of early disease and researchers said they hoped that it would soon become more widely available in the UK.
Indeed, no one knows how long the benefits of tamoxifen or the aromatase inhibitors might linger.
Serono said aromatase inhibitors had shown promise in early tests as potential first-line agents for treating infertility.
Aromatase Inhibitors (Targeted Therapy Drug) Major Producer and Their Market Share
13 ( ANI ): Women being treated with breast cancer drugs known as aromatase inhibitors could ease the joint pain associated with the drugs by engaging in moderate daily exercise, according to a study.
For most of these patients, blocking estrogen activity with aromatase inhibitors represents an effective treatment.